CAS 222036-27-3

7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-

Description:

7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro- is a heterocyclic organic compound characterized by its fused pyrrole and benzothiazole structures. This compound features a bicyclic framework that includes a pyrrole ring and a benzothiazole moiety, contributing to its unique chemical properties. The presence of the carbonyl group (ketone) at the 7-position of the pyrrole enhances its reactivity and potential for forming various derivatives. The dihydro designation indicates that the compound has two additional hydrogen atoms, suggesting it is in a reduced form compared to its fully unsaturated counterparts. This compound may exhibit interesting biological activities, making it a subject of interest in medicinal chemistry and drug development. Its structural features may influence its solubility, stability, and interaction with biological targets. As with many heterocycles, it may also participate in various chemical reactions, including electrophilic substitutions and nucleophilic additions, which can be exploited in synthetic applications. Overall, 7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro- represents a versatile scaffold in organic and medicinal chemistry.

Formula: C₉H₆N₂OS

Synonyms:

• 7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI)

6,8-Dihydro-7h-thiazolo[5,4-e]indol-7-one

CAS: 222036-27-3

6,8-Dihydro-7h-thiazolo[5,4-e]indol-7-one

Purity: 98%

Molecular weight: 190.23g/mol

Ref: 54-OR1034505

6H-THIAZOLO[5,4-E]INDOL-7(8H)-ONE

CAS: 222036-27-3

Purity: 95%

Molecular weight: 190.220001220703

Ref: 10-F858393

6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one

Controlled Product

CAS: 222036-27-3

Applications 6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one is an intermediate in synthesizing Imidazolo-oxindole PKR inhibitor C16 (PKR Inhibitor) (P572500). It is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.
References Jammi, N., et al.: Biochem. Biophys. Res. Commun., 308, 50 (2003); Ingrand, S., et al.: Neurosci. Lett., 409, 192 (2006); Chen, H., et al.: Eur. J. Neurosci., 28, 2003 (2008); Couturier, J., et al.: J. Biol. Chem., 285, 1272 (2010)

Formula: C₉H₆N₂OS

Color and Shape: Neat

Molecular weight: 190.22

Ref: TR-D453658