CAS 22260-51-1

Bromocriptine mesylate

Description:

Bromocriptine mesylate is a synthetic compound primarily used as a dopamine agonist in the treatment of various medical conditions, including Parkinson's disease, hyperprolactinemia, and certain types of acromegaly. It is derived from ergot alkaloids and functions by stimulating dopamine receptors, particularly D2 receptors, which helps to regulate hormonal levels and improve motor control. The mesylate salt form enhances its solubility and stability, making it suitable for pharmaceutical formulations. Bromocriptine mesylate is typically administered orally and is known for its relatively rapid absorption and bioavailability. Common side effects may include nausea, dizziness, and fatigue, reflecting its central nervous system activity. The compound is classified as a prescription medication and should be used under medical supervision due to potential interactions with other drugs and contraindications in certain patient populations. Its chemical structure includes a bromine atom, contributing to its pharmacological properties, and it is often studied for its effects on neuroendocrine functions.

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

InChI: InChI=1S/C32H40BrN5O5.CH4O3S/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18;1-5(2,3)4/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39);1H3,(H,2,3,4)/t18-,23-,24+,25+,31-,32+;/m1./s1

InChI key: InChIKey=NOJMTMIRQRDZMT-GSPXQYRGSA-N

SMILES: O[C@]12N(C(=O)[C@@](NC(=O)[C@@H]3C=C4C=5C=6C(C[C@]4(N(C)C3)[H])=C(Br)NC6C=CC5)(C(C)C)O1)[C@@H](CC(C)C)C(=O)N7[C@]2(CCC7)[H].S(C)(=O)(=O)O

Synonyms:

• (+)-Bromocriptine methanesulfonate
• (5'Alpha)-2-Bromo-12'-Hydroxy-5'-(2-Methylpropyl)-3',6',18-Trioxo-2'-(Propan-2-Yl)Ergotaman Methanesulfonate (1:1)
• (5Xi,5'Alpha)-2-Bromo-12'-Hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-3',6',18-Trioxoergotaman Methanesulfonate (Salt)
• (8Xi,12'Xi)-2-Bromo-12'-Hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-3',6',18-Trioxoergotaman Methanesulfonate (Salt)
• 2-bromo-A-ergocryptine methanesulfonate salt
• 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv.
• Bagren
• Bromocriptine Mesylate
• Bromocryptine mesylate
• Bromocryptine methanesulfonate
• Cb 154
• Cycloset
• Ergocryptine, 2-bromo-, monomethanesulfonate (salt)
• Ergotaman-3′,6′,18-trione, 2-bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)-, (5α)-, methanesulfonate (1:1)
• Ergotaman-3′,6′,18-trione, 2-bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)-, (5′α)-, monomethanesulfonate (salt)
• Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• Parlodel

Bromocriptine Mesilate

CAS: 22260-51-1

Color and Shape: Neat

Ref: 61-FOR1159.00

Bromocriptine mesilate

CAS: 22260-51-1

Bromocriptine mesilate

Formula: C₃₂H₄₀BrN₅O₅

Purity: 86.2%

Color and Shape: Off-White

Molecular weight: 653.22128

Ref: 47-50

BROMOCRIPTINE MESILATE FOR SYSTEM SUITABILITY CRS

CAS: 22260-51-1

BROMOCRIPTINE MESILATE FOR SYSTEM SUITABILITY CRS

Formula: C₃₃H₄₄BrN₅O₈S

Molecular weight: 750.7002

Ref: 41-Y0000677

BROMOCRIPTINE MESILATE CRS

CAS: 22260-51-1

BROMOCRIPTINE MESILATE CRS

Formula: C₃₃H₄₄BrN₅O₈S

Color and Shape: Crystalline Powder. White. Whitish. Powder.

Molecular weight: 750.7002

Ref: 41-B1150000

Bromocriptine Mesylate

CAS: 22260-51-1

Alkaloids of rye ergot and their derivatives; salts thereof, nesoi

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Color and Shape: White Off-White Powder

Molecular weight: 749.2094

Ref: 45-1076501

Bromocriptine mesylate

CAS: 22260-51-1

Formula: C₃₃H₄₄BrN₅O₈S

Purity: 99%

Color and Shape: Solid

Molecular weight: 750.7002

Ref: IN-DA007P10

Bromocriptine Mesylate

CAS: 22260-51-1

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 654.61 96.10

Ref: 4Z-B-333

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate

Molecular weight: 750.7g/mol

Ref: 54-BI12183

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate

Purity: ≥98%

Molecular weight: 750.7g/mol

Ref: 54-BUP17549

Bromocriptine Mesilate

Controlled Product

CAS: 22260-51-1

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Color and Shape: Neat

Molecular weight: 750.70

Ref: 86-MM1159.00

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)

Formula: C₃₃H₄₄BrN₅O₈S

Purity: 99.85% - 99.96%

Color and Shape: White Solid

Molecular weight: 750.7

Ref: TM-T5842

Bromocryptine mesylate

CAS: 22260-51-1

Formula: C₃₂H₄₀BrN₅O₅·CH₄SO₃

Purity: 98.0 - 102.0 % (anhydrous basis)

Color and Shape: White powder

Molecular weight: 750.70

Ref: 7W-GP6938

Bromocriptine mesylate

Controlled Product

CAS: 22260-51-1

Dopamine (D2) agonist; inhibits neuronal NOS enzyme

Formula: C₃₂H₄₀BrN₅O₅•CH₄O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 750.7 g/mol

Ref: 3D-FB19032

Bromocriptine mesylate - Bio-X ™

Controlled Product

CAS: 22260-51-1

Bromocriptine is a dopamine D2 receptor agonist that is used for the treatment of galactorrhoea which is due to hyperprolactinemia and other prolactin-related conditions. This drug is an ergot alkaloid derivative that inhibits prolactin secretion. Additionally, it can be used to management signs and symptoms of Parkinsonian syndrome. Research has indicated this drug for pulmonary fibrosis as well.

Formula: C₃₃H₄₄BrN₅O₈S

Purity: Min. 99 Area-%

Color and Shape: Powder

Molecular weight: 750.7 g/mol

Ref: 3D-BB164266

2-Bromo α-Ergocryptine Mesylate

Controlled Product

CAS: 22260-51-1

Applications The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. 2-Bromo-α-Ergocryptine is a dopamine receptor agonist and a derivative of the ergotoxin group of ergot alkaloids (2). It is also a prolactin inhibitor (3).
References (1) Ptácek, R., et al.: Med Sci Monit. 17, RA215 (2011) (2) Lieberman, A. N. and Goldstein, M.: Pharmacol Rev. 37, 217 (1985) (3) Nazli, K., et al.: Br J Clin Pract. 43, 322 (1989)

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Color and Shape: White To Off-White

Molecular weight: 750.70

Ref: TR-B682600