CAS 2226077-86-5

3-Azabicyclo[3.2.1]octan-8-amine, 3-(6-methyl-4-pyrimidinyl)-N-[(9R)-6,7,8,9-tetrahydro-9-(2,3,4-trifluorophenyl)-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl]-

Description:

3-Azabicyclo[3.2.1]octan-8-amine, 3-(6-methyl-4-pyrimidinyl)-N-[(9R)-6,7,8,9-tetrahydro-9-(2,3,4-trifluorophenyl)-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl]- is a complex organic compound characterized by its bicyclic structure and the presence of multiple functional groups. The compound features a bicyclic amine core, which contributes to its potential biological activity, particularly in pharmacology. The presence of a pyrimidine ring and a triazole moiety suggests that it may interact with various biological targets, possibly influencing neurotransmitter systems or other cellular pathways. The trifluorophenyl group indicates a degree of lipophilicity, which can affect the compound's solubility and permeability. Additionally, the stereochemistry at the tetrahydro-triazoloazepine portion may play a crucial role in its biological efficacy and receptor binding. Overall, this compound's unique structural features make it a candidate for further investigation in medicinal chemistry, particularly in the development of therapeutics targeting neurological or psychiatric disorders.

Formula: C₂₅H₂₈F₃N₇

Synonyms:

• 3-Azabicyclo[3.2.1]octan-8-amine, 3-(6-methyl-4-pyrimidinyl)-N-[(9R)-6,7,8,9-tetrahydro-9-(2,3,4-trifluorophenyl)-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl]-

(9R)-RO7185876

CAS: 2226077-86-5

(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.

Formula: C₂₅H₂₈F₃N₇

Color and Shape: Solid

Molecular weight: 483.532

Ref: TM-T204358