CAS 2226077-86-5

3-Azabicyclo[3.2.1]octan-8-amine, 3-(6-methyl-4-pyrimidinyl)-N-[(9R)-6,7,8,9-tetrahydro-9-(2,3,4-trifluorophenyl)-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl]-

Description:

3-Azabicyclo[3.2.1]octan-8-amine, 3-(6-methyl-4-pyrimidinyl)-N-[(9R)-6,7,8,9-tetrahydro-9-(2,3,4-trifluorophenyl)-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl]- is a complex organic compound characterized by its bicyclic structure and the presence of multiple functional groups. The compound features a bicyclic amine core, which contributes to its potential biological activity, particularly in pharmacology. The presence of a pyrimidine ring and a triazole moiety suggests that it may interact with various biological targets, possibly influencing neurotransmitter systems or other cellular pathways. The trifluorophenyl group indicates a degree of lipophilicity, which can affect the compound's solubility and permeability. Additionally, the stereochemistry at the tetrahydro-triazoloazepine portion may play a crucial role in its biological efficacy and receptor binding. Overall, this compound's unique structural features make it a candidate for further investigation in medicinal chemistry, particularly in the development of therapeutics targeting neurological or psychiatric disorders.

Formula: C₂₅H₂₈F₃N₇

InChI: InChI=1S/C25H28F3N7/c1-14-10-20(30-13-29-14)34-11-15-5-6-16(12-34)23(15)31-25-32-24-18(4-2-3-9-35(24)33-25)17-7-8-19(26)22(28)21(17)27/h7-8,10,13,15-16,18,23H,2-6,9,11-12H2,1H3,(H,31,33)/t15-,16+,18-,23?/m1/s1

InChI key: XGTZKVXMDSWEOE-IPSMIJQESA-N

SMILES: CC1=CC(=NC=N1)N2C[C@H]3CC[C@@H](C2)C3NC4=NN5CCCC[C@@H](C5=N4)C6=C(C(=C(C=C6)F)F)F

Synonyms:

• 3-Azabicyclo[3.2.1]octan-8-amine, 3-(6-methyl-4-pyrimidinyl)-N-[(9R)-6,7,8,9-tetrahydro-9-(2,3,4-trifluorophenyl)-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl]-

(9R)-RO7185876

CAS: 2226077-86-5

(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.

Formula: C₂₅H₂₈F₃N₇

Color and Shape: Solid

Molecular weight: 483.532

Ref: TM-T204358