CAS 2229036-62-6

MS4078

CAS: 2229036-62-6

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

Formula: C₄₅H₅₂ClN₉O₈S

Purity: 98.74%

Color and Shape: Solid

Molecular weight: 914.47

Ref: TM-T16153

2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

CAS: 2229036-62-6

Formula: C₄₅H₅₂ClN₉O₈S

Purity: 98%

Color and Shape: Solid

Molecular weight: 914.4679

Ref: IN-DA01KFT4

2-(4-(4-((5-Chloro-4-((2-(Isopropylsulfonyl)Phenyl)Amino)Pyrimidin-2-Yl)Amino)-5-Isopropoxy-2-Methylphenyl)Piperidin-1-Yl)-N-(2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethyl)Aceta

CAS: 2229036-62-6

2-(4-(4-((5-Chloro-4-((2-(Isopropylsulfonyl)Phenyl)Amino)Pyrimidin-2-Yl)Amino)-5-Isopropoxy-2-Methylphenyl)Piperidin-1-Yl)-N-(2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Amino)Ethyl)Aceta

Purity: 98%

Molecular weight: 914.47g/mol

Ref: 54-OR1023195

MS4078

CAS: 2229036-62-6

MS4078

Purity: ≥98%

Molecular weight: 914.47g/mol

Ref: 54-BUP05443

MS4078

CAS: 2229036-62-6

Purity: 98%

Molecular weight: 914.48

Ref: 10-F986816

MS4078

CAS: 2229036-62-6

MS4078 is a heterobifunctional linker that binds to protein targets and delivers cytotoxic drugs to cancer cells. MS4078 was designed with an emphasis on minimal toxicity and the ability to target different cellular proteins. The linker has shown minimal toxicity in pre-clinical studies, which may be due to its selective binding affinity for cancer cells. MS4078 has also been shown to be potently active against drug-resistant cancers, such as colorectal cancer.

Formula: C₄₅H₅₂ClN₉O₈S

Purity: Min. 95%

Molecular weight: 914.47 g/mol

Ref: 3D-EPD03662