CAS 2229036-62-6

Formula: C45H52ClN9O8S

InChI: InChI=1S/C45H52ClN9O8S/c1-25(2)63-36-22-30(27(5)21-34(36)51-45-49-23-31(46)41(53-45)50-32-10-6-7-12-37(32)64(61,62)26(3)4)28-15-19-54(20-16-28)24-39(57)48-18-17-47-33-11-8-9-29-40(33)44(60)55(43(29)59)35-13-14-38(56)52-42(35)58/h6-12,21-23,25-26,28,35,47H,13-20,24H2,1-5H3,(H,48,57)(H,52,56,58)(H2,49,50,51,53)

InChI key: AYMGZLUKTNXEMY-UHFFFAOYSA-N

SMILES: CC1=CC(=C(C=C1C2CCN(CC2)CC(=O)NCCNC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O)OC(C)C)NC6=NC=C(C(=N6)NC7=CC=CC=C7S(=O)(=O)C(C)C)Cl

MS4078

CAS: 2229036-62-6

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

Formula: C₄₅H₅₂ClN₉O₈S

Purity: 98.74%

Color and Shape: Yellow Solid

Molecular weight: 914.47

Ref: TM-T16153

MS4078

CAS: 2229036-62-6

MS4078

Formula: C₄₅H₅₂ClN₉O₈S

Purity: ≥98%

Molecular weight: 914.47

Ref: 54-BUP05443

MS4078

CAS: 2229036-62-6

MS4078

Formula: C₄₅H₅₂ClN₉O₈S

Purity: 98%

Molecular weight: 914.47

Ref: 54-OR1023195

MS4078

CAS: 2229036-62-6

2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

Formula: C₄₅H₅₂ClN₉O₈S

Purity: 98%

Molecular weight: 914.47

Ref: IN-DG00784926

MS4078

CAS: 2229036-62-6

Purity: 98%

Molecular weight: 914.48

Ref: 10-F986816

2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

CAS: 2229036-62-6

Formula: C₄₅H₅₂ClN₉O₈S

Purity: 98%

Color and Shape: Solid

Molecular weight: 914.4679

Ref: IN-DA01KFT4

MS4078

CAS: 2229036-62-6

MS4078 is a heterobifunctional linker that binds to protein targets and delivers cytotoxic drugs to cancer cells. MS4078 was designed with an emphasis on minimal toxicity and the ability to target different cellular proteins. The linker has shown minimal toxicity in pre-clinical studies, which may be due to its selective binding affinity for cancer cells. MS4078 has also been shown to be potently active against drug-resistant cancers, such as colorectal cancer.

Formula: C₄₅H₅₂ClN₉O₈S

Purity: Min. 95%

Molecular weight: 914.47 g/mol

Ref: 3D-EPD03662