CAS 2248728-49-4

Formula: C15H16N6

InChI: InChI=1S/C15H16N6/c1-9-11(7-17-21-9)13-18-12-8-16-6-3-10(12)14(19-13)20-15(2)4-5-15/h3,6-8H,4-5H2,1-2H3,(H,17,21)(H,18,19,20)

InChI key: HQFDCITUHVQXEV-UHFFFAOYSA-N

SMILES: CC1=C(C=NN1)C2=NC3=C(C=CN=C3)C(=N2)NC4(CC4)C

LATS-IN-2

CAS: 2248728-49-4

LATS-IN-2 is a potent inhibitor of LATS, demonstrating significant inhibitory activity against LATS1 with an IC50 value of 1.3 nM. By inhibiting LATS kinase activity, LATS-IN-2 reduces the phosphorylation of YAP. Additionally, LATS-IN-2 increases the thickness of mouse epidermis and can be used in research on ocular diseases, such as limbal stem cell deficiency and corneal endothelial dysfunction.

Formula: C₁₅H₁₆N₆

Molecular weight: 280.34

Ref: TM-T213611