CAS 22518-27-0

4-(4-Chlorophenyl)-2-pyrrolidinone

Description:

4-(4-Chlorophenyl)-2-pyrrolidinone, with the CAS number 22518-27-0, is a chemical compound characterized by its pyrrolidinone structure, which features a five-membered lactam ring. This compound contains a chlorophenyl group, indicating the presence of a chlorine atom attached to a phenyl ring, which contributes to its chemical reactivity and potential biological activity. It is typically a white to off-white solid and is soluble in organic solvents, reflecting its moderate polarity. The presence of the pyrrolidinone moiety suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, due to its ability to interact with biological targets. Additionally, the chlorophenyl substituent may enhance its lipophilicity, influencing its pharmacokinetic properties. Safety and handling precautions should be observed, as with many organic compounds, due to potential toxicity or environmental impact. Overall, 4-(4-Chlorophenyl)-2-pyrrolidinone is of interest in various fields, including organic synthesis and drug development.

Formula: C₁₀H₁₀ClNO

InChI: InChI=1S/C10H10ClNO/c11-9-3-1-7(2-4-9)8-5-10(13)12-6-8/h1-4,8H,5-6H2,(H,12,13)

InChI key: InChIKey=OVRPDYOZYMCTAK-UHFFFAOYSA-N

SMILES: O=C1CC(C2=CC=C(Cl)C=C2)CN1

Synonyms:

• (±)-Baclofen lactam
• 2-Pyrrolidinone, 4-(4-Chlorophenyl)-
• 2-Pyrrolidinone, 4-(p-chlorophenyl)-
• 4-(4-Chlorophenyl)-2-pyrrolidone
• 4-(4-Chlorophenyl)pyrrolidin-2-one
• 4-(4-Chlorophenyl)-2-pyrrolidinone

BACLOFEN IMPURITY A CRS

CAS: 22518-27-0

BACLOFEN IMPURITY A CRS

Formula: C₁₀H₁₀ClNO

Molecular weight: 195.6455

Ref: 41-B0200050

Baclofen Related Compound A (4-(4-Chlorophenyl)-2-pyrrolidinone)

CAS: 22518-27-0

Lactams, nesoi

Formula: C₁₀H₁₀ClNO

Color and Shape: White Crystals

Molecular weight: 195.04509

Ref: 45-1048222

4-(4-Chlorophenyl)pyrrolidin-2-one

CAS: 22518-27-0

Formula: C₁₀H₁₀ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 195.6455

Ref: IN-DA006XPH

4-(4-Chlorophenyl)pyrrolidin-2-one

CAS: 22518-27-0

4-(4-Chlorophenyl)pyrrolidin-2-one

Purity: 98%

Ref: 54-OR1042345

Baclofen EP Impurity A (Baclofen USP Related Compound A)

CAS: 22518-27-0

Formula: C₁₀H₁₀ClNO

Color and Shape: White To Off-White Solid

Molecular weight: 195.65

Ref: 4Z-B-403

Baclofen EP Impurity A

Controlled Product

CAS: 22518-27-0

Formula: C₁₀H₁₀ClNO

Color and Shape: Neat

Molecular weight: 195.65

Ref: 86-MM1235.02

Baclofen Impurity 27

CAS: 22518-27-0

Formula: C₁₃H₁₅ClN₂O

Molecular weight: 250.73

Ref: 4Z-B-4034

Baclofen EP Impurity A

CAS: 22518-27-0

Formula: C₁₀H₁₀ClNO

Molecular weight: 195.65

Ref: ST-EA-CP-B3001

4-(4-Chlorophenyl)-2-pyrrolidinone

Controlled Product

CAS: 22518-27-0

Impurity Baclofen EP Impurity A
Applications 4-(4-Chlorophenyl)-2-pyrrolidinone is used in the preparation of potential and selective antagonists of the α1A adrenergic receptor (1,2). It is an impurity of Baclofen (B108000), a specific GABA-B receptor agonist. Muscle relaxant (skeletal).
References (1) Whitlock, G. et al.: Bioorg. med. Chem. Lett., 19, 3118 (2009)(2) Brogden, R.N., et al.: Drugs, 8,1 (1974)

Formula: C₁₀H₁₀ClNO

Color and Shape: Neat

Molecular weight: 195.65

Ref: TR-C379450

4-(4-CHLOROPHENYL)PYRROLIDIN-2-ONE

CAS: 22518-27-0

Formula: C₁₀H₁₀ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 195.65

Ref: 10-F303515

4-(4-Chlorophenyl)-2-pyrrolidinone

CAS: 22518-27-0

4-(4-Chlorophenyl)-2-pyrrolidinone (4CPP) is an anti-convulsant drug that is used to treat epilepsy. It has a high boiling point, allowing it to be used in liquid chromatography methods. 4CPP is also used as a solvent for drugs and excipients in the pharmaceutical industry, and can be obtained through chemical synthesis or by dehydration of butyric acid. The reaction products are trehalose, which is a sugar that prevents the formation of ice crystals, and gabapentin, which is an anti-convulsant drug. 4CPP can be synthesized on an on-line basis using electrospray ionization with a liquid chromatograph/mass spectrometer system. It has been shown to have clinical use in the treatment of epilepsy.

Formula: C₁₀H₁₀ClNO

Purity: Min. 95%

Molecular weight: 195.65 g/mol

Ref: 3D-FC177468