CAS 22560-50-5

Clodronate sodium

Description:

Clodronate sodium is a bisphosphonate compound primarily used in the treatment of bone disorders, particularly in conditions such as osteoporosis and metastatic bone disease. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The chemical formula for clodronate sodium is C5H6Cl2NaO3P, and it is characterized by its ability to bind to hydroxyapatite in bone tissue. This compound is typically administered orally or intravenously, depending on the clinical indication. Clodronate sodium is known for its relatively low toxicity profile compared to other bisphosphonates, making it a preferred choice in certain therapeutic contexts. It is also utilized in research settings to study bone metabolism and the effects of bisphosphonates on various biological processes. As with any medication, potential side effects may include gastrointestinal disturbances and, in rare cases, osteonecrosis of the jaw, necessitating careful monitoring during treatment.

Formula: CH₂Cl₂Na₂O₆P₂

InChI: InChI=1/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key: InChIKey=OQNIOBHHYSEHCE-UHFFFAOYSA-N

SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl.[Na]

Synonyms:

• (Dichloromethylene)diphosphonate disodium
• Bm 06011
• Bonefos
• Clasteon
• Clodronate
• Clodronate disodium
• Clodronate disodium salt
• Clodronate sodium
• Clodronic Acid Disodium Salt
• DClMDP
• Dichloromethylenebisphosphonic acid disodium salt
• Dichloromethylenediphosphonic Acid Disodium Salt
• Difoafonal
• Diphosfonal
• Disodium (Dichloromethanediyl)Bis[Hydrogen (Phosphonate)]
• Disodium (dichloromethane)diphosphonate
• Disodium (dichloromethylene)bisphosphonate
• Disodium (dichloromethylene)diphosphonate
• Disodium clodronate
• Disodium dichloromethylenebis(hydrogenphosphonate) tetrahydrate
• Lodronate
• Loron
• Mebonat
• Ossiten
• Ostac
• Phosphonic acid, (dichloromethylene)bis-, disodium salt
• Phosphonic acid, (dichloromethylene)di-, disodium salt
• Phosphonic acid, P,P′-(dichloromethylene)bis-, sodium salt (1:2)
• Sodium (dichloromethylene)diphosphonate
• Sodium clodronate
• DICHLOROMETHYLENEDIPHOPHONIC ACID DISODIUM SALT
• disodium dihydrogen (dichloromethylene)diphosphonate
• sodiumclodronate
• (dichloromethylene)bis-phosphonicacidisodiumsalt
• dichloromethanediphosphonate
• Clodronate Disodium, Bonefos, Clasteon, Clastoban
• CL2MDP
• clodronatesodium
• DICHLOROMETHYLENEDIPHOSPHONIC ACID
• (dichloromethylene)di-phosphonicacidisodiumsalt
• ClodronateAcidDisodiumSalt
• DMDP
• chlodronatesodium
• disodiumclodronate

CLODRONATE DISODIUM TETRAHYDRATE CRS

CAS: 22560-50-5

CLODRONATE DISODIUM TETRAHYDRATE CRS

Formula: CH₂Cl₂Na₂O₆P₂

Color and Shape: Added

Molecular weight: 288.856

Ref: 41-Y0000888

Clodronate Disodium

CAS: 22560-50-5

Clodronate Disodium

Formula: CH₂Cl₂Na₂O₆P₂

Purity: 97%

Molecular weight: 288.86

Ref: 54-OR1028888

Clodronic acid disodium salt

CAS: 22560-50-5

Clodronic acid disodium salt

Formula: CH₄Cl₂O₆P₀·2Na

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 288.86

Ref: 54-BUP15844

Clodronic Acid Disodium Salt Hydrate

Controlled Product

CAS: 22560-50-5

Applications Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.
References Plosker, G.L., et al.: Drugs, 47, 945 (1994), Diel, I.J., et al.: N. Engl. J. Med., 339, 357 (1998)

Formula: CH₂Cl₂O₆P₂·2Na

Color and Shape: Neat

Molecular weight: 288.86

Ref: TR-C586875

Clodronic acid disodium salt

CAS: 22560-50-5

Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.

Formula: CH₄Cl₂O₆P₀·2Na

Purity: 99.63% - ≥98%

Color and Shape: White Solid

Molecular weight: 288.86

Ref: TM-T6451

Clodronic acid disodium salt

CAS: 22560-50-5

Clodronic acid disodium salt is a drug that can be used as a treatment for bowel disease. It binds to the chemoattractant protein and inhibits the activation of toll-like receptor 4, which is involved in inflammatory reactions. Clodronic acid also has an effect on polymorphonuclear leucocytes, inhibiting the production of cytokines and other inflammatory mediators. Clodronic acid has been shown to reduce neuronal death in experimental models and inhibit mitochondrial membrane potential in leukemic mice. The drug acts by binding to basic proteins in bone cells, preventing the release of calcium from bone stores into the blood stream. The monosodium salt form is more soluble than clodronate, which is a disodium salt.

Formula: CH₂Cl₂Na₂O₆P₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 288.86 g/mol

Ref: 3D-FC20495

Clodronic acid disodium salt

CAS: 22560-50-5

Sodium (dichloro(phosphono)methyl)phosphonate

Formula: CH₂Cl₂Na₂O₆P₂

Purity: 99%

Molecular weight: 288.86

Ref: IN-DG121926

(Dichloromethylene)diphosphonic acid, disodium salt

CAS: 22560-50-5

Formula: CH₂Cl₂Na₂O₆P₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 288.85

Ref: 10-F449661

(Dichloromethylene)diphosphonate disodium

CAS: 22560-50-5

Formula: CH₂Cl₂Na₂O₆P₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 288.8560

Ref: IN-DA006XK8