CAS 226700-81-8

Fosamprenavir calcium

Description:

Fosamprenavir calcium is a prodrug of amprenavir, primarily used as an antiretroviral medication in the treatment of HIV infection. It is classified as a protease inhibitor, which works by inhibiting the HIV protease enzyme, thereby preventing viral replication. The compound is characterized by its calcium salt form, which enhances its solubility and bioavailability. Fosamprenavir is typically administered orally and is often used in combination with other antiretroviral agents to improve therapeutic efficacy and reduce the risk of resistance. The substance is known for its favorable pharmacokinetic profile, including a relatively long half-life, allowing for once or twice daily dosing. Common side effects may include gastrointestinal disturbances, rash, and potential interactions with other medications due to its metabolism via the cytochrome P450 system. Overall, fosamprenavir calcium plays a significant role in the management of HIV, contributing to improved patient outcomes when used as part of a comprehensive antiretroviral therapy regimen.

Formula: C₂₅H₃₄CaN₃O₉PS

InChI: InChI=1/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/t21-,23-,24+;/m0./s1

InChI key: InChIKey=XOGQXKBFJZURRD-HQROKSDRSA-N

SMILES: [C@H]([C@H](CC1=CC=CC=C1)NC(O[C@H]2CCOC2)=O)(CN(S(=O)(=O)C3=CC=C(N)C=C3)CC(C)C)OP(=O)(O)O.[Ca]

Synonyms:

• Calcium [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonatooxy-butan-2-yl]carbamate
• Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, C-[(3S)-tetrahydro-3-furanyl] ester, calcium salt (1:1)
• Fosamprenavir calcium salt
• Gw 433908G
• Lexiva
• Telzir
• calcium (2R,3S)-1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-4-phenyl-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butan-2-yl phosphate
• carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, (3S)-tetrahydro-3-furanyl ester, calcium salt (1:1)
• Fosamprenavir calcium
• FOSAMPRENAVIR
• Fosamprenavir & Fosamprenavir Calcium

Fosamprenavir Calcium

CAS: 226700-81-8

Sulfonamides used as drugs

Formula: C₂₅H₃₄CaN₃O₉PS

Color and Shape: White Off-White Powder

Molecular weight: 623.13793

Ref: 45-1283368

Fosamprenavir calcium

CAS: 226700-81-8

Formula: C₂₅H₃₄CaN₃O₉PS

Purity: 98%

Color and Shape: Solid

Molecular weight: 623.6689

Ref: IN-DA006X1D

Fosamprenavir Calcium Salt

CAS: 226700-81-8

Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility.

Formula: C₂₅H₃₄CaN₃O₉PS

Purity: 98.68%

Color and Shape: White Microcrystalline Needles

Molecular weight: 623.67

Ref: TM-T8238

Fosamprenavir Calcium Salt

CAS: 226700-81-8

Fosamprenavir Calcium Salt

Purity: ≥98%

Molecular weight: 623.67g/mol

Ref: 54-BUP02032

Fosamprenavir Calcium

CAS: 226700-81-8

Formula: C₂₅H₃₄N₃O₉PS·Ca

Color and Shape: White To Off-White Solid

Molecular weight: 583.59 40.08

Ref: 4Z-F-1511

Fosamprenavir Calcium Salt

Controlled Product

CAS: 226700-81-8

Applications HIV protease inhibitor; water soluble prodrug of amprenavir.
References Falcoz, C., et al.: J. Clin. Pharmacol., 42, 887 92002), Chapman, T.M., et al.: Drugs, 64, 2101 (2004)

Formula: C₂₅H₃₄N₃O₉PS·Ca

Color and Shape: White To Off-White

Molecular weight: 623.67

Ref: TR-F727250

Fosamprenavir-d4 Calcium Salt

Controlled Product

CAS: 226700-81-8

Applications HIV protease inhibitor; water soluble prodrug of amprenavir.
References Falcoz, C., et al.: J. Clin. Pharmacol., 42, 887 92002), Chapman, T.M., et al.: Drugs, 64, 2101 (2004)

Formula: C₂₅H₃₀D₄CaN₃O₉PS

Color and Shape: Neat

Molecular weight: 627.69

Ref: TR-F727252

FOSAMPRENAVIR CALCIUM

CAS: 226700-81-8

Purity: 98%

Molecular weight: 623.6699829

Ref: 10-F826368