CAS 229030-20-0

L-Arginine,L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-L-arginyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-,cyclic (4®13)-disulfide

Description:

The chemical substance known as "L-Arginine, L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-L-arginyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4®13)-disulfide" with CAS number 229030-20-0 is a complex peptide that features multiple amino acid residues, including L-arginine, L-alanine, L-cysteine, L-tyrosine, and L-lysine. Its structure indicates the presence of a cyclic disulfide bond, which is significant for its stability and biological activity. The inclusion of aromatic and sulfur-containing amino acids suggests potential roles in biochemical processes, such as antioxidant activity or enzyme regulation. This compound may exhibit unique properties due to its cyclic nature and the specific arrangement of amino acids, which can influence its interaction with biological targets. As a peptide, it may be involved in various physiological functions, including signaling pathways and metabolic processes. Further studies would be necessary to elucidate its specific biological roles and potential applications in medicine or biotechnology.

Formula: C₉₀H₁₄₁N₃₃O₁₈S₂

Synonyms:

• 68:PN: WO2008075370 SEQID: 69 claimed protein
• 69: PN: WO2008075369 SEQID: 69claimed protein
• T 140
• T 140 (peptide)

Polyphemusin II-Derived Peptide

CAS: 229030-20-0

Showed the highest inhibitory activity against the T cell line-tropic HIV-1 infection through its specific binding to a chemokine receptor CXCR4 (IC₅₀ = 0.18 ± 0.041 nM) and the strongest inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody to CXCR4 (IC₅₀ = 2.3 ± 0.20 nM).

Formula: C₉₀H₁₄₁N₃₃O₁₈S₂

Purity: 97.3%

Color and Shape: White Powder

Molecular weight: 2037.45

Ref: 01-4029155

Polyphemusin II-Derived Peptide

CAS: 229030-20-0

T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.

Formula: C₉₀H₁₄₁N₃₃O₁₈S₂

Color and Shape: Solid

Molecular weight: 2037.42

Ref: TM-T76654

Polyphemusin II-Derived Peptide

CAS: 229030-20-0

Polyphemusin II-derived peptide H-Arg-Arg-2-Nal-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit (PIIH) is a cyclic polypeptide with a disulfide bond. PIIH binds to the alpha4beta1 integrin receptor, which is involved in the adhesion of leukocytes to endothelial cells and the migration of monocytes and lymphocytes. PIIH has been shown to be a potent inhibitor of chemokine binding to cxcr4, an important regulator of inflammatory response in mouse tumor models. PIIH also inhibits hiv infection as it inhibits the release of virus from infected cells. This pharmacological effect is mediated by its ability to bind HIV gp120 and block gp120 binding to CD4 receptors on target cells.

Formula: C₉₀H₁₄₁N₃₃O₁₈S₂

Purity: Min. 95%

Molecular weight: 2,037.43 g/mol

Ref: 3D-FP109318