CAS 23047-25-8

Lofepramine

Description:

Lofepramine is a chemical compound primarily used as an antidepressant, classified as a selective norepinephrine and dopamine reuptake inhibitor (NDRI). It is structurally related to the tricyclic antidepressant class but is distinct in its mechanism of action, focusing on enhancing the levels of norepinephrine and dopamine in the synaptic cleft. Lofepramine is known for its relatively favorable side effect profile compared to traditional tricyclic antidepressants, as it tends to have a lower incidence of sedation and anticholinergic effects. The compound is typically administered in its hydrochloride salt form, which enhances its solubility and bioavailability. Its pharmacokinetics involve extensive metabolism in the liver, leading to active metabolites that contribute to its therapeutic effects. Lofepramine is primarily indicated for the treatment of major depressive disorder and has been studied for its potential in treating other mood disorders. As with any medication, it is essential to consider contraindications and potential interactions with other drugs when prescribing lofepramine.

Formula: C₂₆H₂₇ClN₂O

InChI: InChI=1/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3

InChI key: InChIKey=SAPNXPWPAUFAJU-UHFFFAOYSA-N

SMILES: C(CCN(CC(=O)C1=CC=C(Cl)C=C1)C)N2C=3C(CCC=4C2=CC=CC4)=CC=CC3

Synonyms:

• 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethanone
• 1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl](methyl)amino}ethanone
• 5-[3-[N-Methyl-N-(p-chlorophenacyl)amino]propyl]-10,11-dihydro-5H-dibenz[b,f]azepine
• Acetophenone, 4′-chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-
• Amplit
• Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-
• Leo 640
• Lofepramine
• Lomont
• Lopramine
• Gamanil
• 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone

Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-

CAS: 23047-25-8

Formula: C₂₆H₂₇ClN₂O

Purity: 97%

Color and Shape: Solid

Molecular weight: 418.9584

Ref: IN-DA002M08

Lofepramine

CAS: 23047-25-8

Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine.

Formula: C₂₆H₂₇ClN₂O

Purity: 98.38%

Color and Shape: Crystals From Methanol Or Acetone Solid

Molecular weight: 418.96

Ref: TM-T15773

Lofepramine

CAS: 23047-25-8

Formula: C₂₆H₂₇N₂OCl

Purity: (HPLC) ≥ 97.0%

Color and Shape: Light yellow to beige powder

Molecular weight: 418.97

Ref: 7W-GP2863

Lofepramine

CAS: 23047-25-8

Lofepramine

Purity: ≥98%

Molecular weight: 418.96g/mol

Ref: 54-BUP05747

Lofepramine

CAS: 23047-25-8

Serotonin and norepinephrine reuptake inhibitor; anti-depressant

Formula: C₂₆H₂₇ClN₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 418.96 g/mol

Ref: 3D-FL24917

Lofepramine - Bio-X ™

CAS: 23047-25-8

Lofepramine is a psychoactive drug that belongs to the class of tricyclic antidepressants. It is used to treat depression and anxiety disorders. This drug works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine and as a result these neurotransmitters remain active in the brain for a longer period, which can help improve mood and alleviate symptoms of depression.

Formula: C₂₆H₂₇ClN₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 418.96 g/mol

Ref: 3D-BL164630

Lofepramine

CAS: 23047-25-8

Formula: C₂₆H₂₇ClN₂O

Color and Shape: Neat

Molecular weight: 418.96

Ref: TR-L469380