CAS 23047-25-8
:Lofepramine
Description:
Lofepramine is a chemical compound primarily used as an antidepressant, classified as a selective norepinephrine and dopamine reuptake inhibitor (NDRI). It is structurally related to the tricyclic antidepressant class but is distinct in its mechanism of action, focusing on enhancing the levels of norepinephrine and dopamine in the synaptic cleft. Lofepramine is known for its relatively favorable side effect profile compared to traditional tricyclic antidepressants, as it tends to have a lower incidence of sedation and anticholinergic effects. The compound is typically administered in its hydrochloride salt form, which enhances its solubility and bioavailability. Its pharmacokinetics involve extensive metabolism in the liver, leading to active metabolites that contribute to its therapeutic effects. Lofepramine is primarily indicated for the treatment of major depressive disorder and has been studied for its potential in treating other mood disorders. As with any medication, it is essential to consider contraindications and potential interactions with other drugs when prescribing lofepramine.
Formula:C26H27ClN2O
InChI:InChI=1/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
InChI key:InChIKey=SAPNXPWPAUFAJU-UHFFFAOYSA-N
SMILES:C(CCN(CC(=O)C1=CC=C(Cl)C=C1)C)N2C=3C(CCC=4C2=CC=CC4)=CC=CC3
Synonyms:- 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethanone
- 1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl](methyl)amino}ethanone
- 5-[3-[N-Methyl-N-(p-chlorophenacyl)amino]propyl]-10,11-dihydro-5H-dibenz[b,f]azepine
- Acetophenone, 4′-chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-
- Amplit
- Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-
- Leo 640
- Lofepramine
- Lomont
- Lopramine
- Gamanil
- 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone
- See more synonyms
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Lofepramine
CAS:Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine.Formula:C26H27ClN2OPurity:98.38%Color and Shape:Yellow SolidMolecular weight:418.96Lofepramine
CAS:Formula:C26H27N2OClPurity:(HPLC) ≥ 97.0%Color and Shape:Light yellow to beige powderMolecular weight:418.971-(4-Chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)(methyl)amino)ethan-1-one
CAS:Formula:C26H27ClN2OPurity:97%Color and Shape:SolidMolecular weight:418.9584Lofepramine - Bio-X ™
CAS:Lofepramine is a psychoactive drug that belongs to the class of tricyclic antidepressants. It is used to treat depression and anxiety disorders. This drug works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine and as a result these neurotransmitters remain active in the brain for a longer period, which can help improve mood and alleviate symptoms of depression.
Formula:C26H27ClN2OPurity:Min. 95%Color and Shape:PowderMolecular weight:418.96 g/molLofepramine
CAS:Serotonin and norepinephrine reuptake inhibitor; anti-depressant
Formula:C26H27ClN2OPurity:Min. 95%Color and Shape:PowderMolecular weight:418.96 g/molLofepramine
CAS:1-(4-Chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)(methyl)amino)ethan-1-oneFormula:C26H27ClN2OPurity:99%Molecular weight:418.96
![1-(4-Chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)(methyl)amino)ethan-1-one](https://static.cymitquimica.com/products/IN/thumb/DA002M08.jpg)
