CAS 23327-57-3

(±)-Nefopam hydrochloride

Description:

(±)-Nefopam hydrochloride is a synthetic compound primarily recognized for its analgesic properties. It is classified as a non-opioid analgesic and is often used to manage pain, particularly in cases where traditional opioids may not be suitable. The substance exhibits a unique mechanism of action, primarily through the inhibition of the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine, which contributes to its pain-relieving effects. Chemically, it is a racemic mixture, meaning it contains equal parts of two enantiomers, which can exhibit different pharmacological activities. Nefopam hydrochloride is typically administered in its hydrochloride salt form, enhancing its solubility and stability. The compound is known for its relatively low incidence of side effects compared to opioids, making it a valuable alternative in pain management. However, it may still cause some adverse effects, including nausea and dizziness. As with any medication, its use should be guided by a healthcare professional, considering individual patient needs and potential interactions with other medications.

Formula: C₁₇H₁₉NO·ClH

InChI: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

InChI key: InChIKey=CNNVSINJDJNHQK-UHFFFAOYSA-N

SMILES: CN1CC=2C(C(OCC1)C3=CC=CC=C3)=CC=CC2.Cl

Synonyms:

• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride
• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)
• 3,4,5,6-Tetrahydro-5-Methyl-1-Phenyl-1H-2,5-Benzoxazocine Hydrochloride
• 3-Methyl-7-Phenyl-6-Oxa-3-Azabicyclo[6.4.0]Dodeca-8,10,12-Triene Hydrochloride
• 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-5-ium chloride
• Acupan
• Fenazoxine
• Fenazoxine hydrochloride
• Nefopam HCl
• R 738
• Nefopam hydrochloride

5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride

CAS: 23327-57-3

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 289.79998779296875

Ref: 10-F241971

(±)-Nefopam (hydrochloride)

CAS: 23327-57-3

Formula: C₁₇H₂₀ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 289.7998

Ref: IN-DA002MVZ

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride

Formula: C₁₇H₂₀ClNO

Purity: ≥98%

Molecular weight: 289.8

Ref: 54-BUP18744

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.

Formula: C₁₇H₂₀ClNO

Purity: 99.32% - 99.85%

Color and Shape: White Solid

Molecular weight: 289.8

Ref: TM-T0470

Nefopam hydrochloride

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·HCl

Purity: ≥ 98.0%

Color and Shape: White to off-white or beige powder

Molecular weight: 289.80

Ref: 7W-GP9613

Nefopam HCl

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 253.35 36.46

Ref: 4Z-N-371

Nefopam-d4 HCl

CAS: 23327-57-3

Formula: C₁₇H₁₅D₄NO·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 257.37 36.46

Ref: 4Z-N-376

Nefopam Hydrochloride

CAS: 23327-57-3

Nefopam Hydrochloride

Formula: C₁₇H₁₉NOHCl

Purity: >98%

Molecular weight: 289.8

Ref: 54-OR1029203

Nefopam Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 23327-57-3

Color and Shape: Single Solution

Ref: 61-AMP1189.00-01

Nefopam Hydrochloride

CAS: 23327-57-3

Color and Shape: Neat

Ref: 61-FOR1189.00

Nefopam Hydrochloride

Controlled Product

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·ClH

Color and Shape: White To Off-White

Molecular weight: 289.80

Ref: 86-MM1189.00

Nefopam Hydrochloride

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 289.80

Ref: 3B-N1169

Nefopam Hydrochloride

CAS: 23327-57-3

Formula: C₁₇H₁₉NOHCl

Molecular weight: 253.34 : 36.5

Ref: ST-EA-CP-N21000

Nefopam Hydrochloride

Controlled Product

CAS: 23327-57-3

Applications A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bassett, et al.: Br. J. Pharmacol., 37, 69 (1969), Klohs, et al.: Arzneim.-Forsch., 22, 132 (1972), Hell, et al.: Drugs, 19, 249 (1980),

Formula: C₁₇H₁₉NO·ClH

Color and Shape: Neat

Molecular weight: 289.8

Ref: TR-N389400

Nefopam HCl - Bio-X ™

CAS: 23327-57-3

Nefopam is a non-narcotic analgesic drug that has been used in the treatment of chronic pain. It belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Nefopam is also a nasal drug that relieves pain by blocking neurokinin 1 receptor, which reduces the production of prostaglandins. Nefopam acts in the brain and spinal cord to relieve pain through different mechanisms such as antinociceptive effects from triple monoamine reuptake inhibition, and antihyperalgesic activity through modulation of glutamatergic transmission.

Formula: C₁₇H₁₉NO·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 289.8 g/mol

Ref: 3D-FN65100

Nefopam hydrochloride

CAS: 23327-57-3

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride (THPP) is a drug that is used as an analgesic and anti-inflammatory agent. THPP interacts with nonsteroidal anti-inflammatory drugs (NSAIDs) to cause neuronal death. It has been shown to inhibit the plate test for prostaglandin synthesis in human erythrocytes. The disulfide bond between cysteine residues on the protein molecule is susceptible to oxidative cleavage by reactive oxygen species from reactive oxygen species such as hydrogen peroxide and lipid peroxidation products. This can lead to the formation of a thiolate ion and a sulfenic acid intermediate. THPP is also known to produce chronic oral toxicity in rats at doses of 837 mg/kg/day for two months. A chemiluminescence method was used to measure the reaction

Formula: C₁₇H₂₀ClNO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 289.8 g/mol

Ref: 3D-FN26174

N-Hydroxymethyl Nefopam N-Oxide

CAS: 23327-57-3

Formula: C₁₇H₁₉NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 285.35

Ref: 4Z-N-3710