CAS 2351149-20-5

Formula: C27H27F3N2O2

InChI: InChI=1S/C27H27F3N2O2/c1-16-23(24-21(31-16)13-26(2,3)14-22(24)33)25(34)32(4)15-17-6-5-7-19(12-17)18-8-10-20(11-9-18)27(28,29)30/h5-12,31H,13-15H2,1-4H3

InChI key: LKBNJIFCVDFAFI-UHFFFAOYSA-N

SMILES: CC1=C(C2=C(N1)CC(CC2=O)(C)C)C(=O)N(C)CC3=CC(=CC=C3)C4=CC=C(C=C4)C(F)(F)F

TGFβRII-IN-3

CAS: 2351149-20-5

TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) with an IC50 of 4.1 μM. It inhibits TGFβ signaling by promoting protein degradation of TGFβ RII. Additionally, TGFβRI-IN-7 can block the transition from endothelial to mesenchymal states and inhibit cell migration, making it useful for cancer research.

Formula: C₂₇H₂₇F₃N₂O₂

Color and Shape: Solid

Molecular weight: 468.51

Ref: TM-T209758