CAS 23541-50-6

Daunorubicin hydrochloride

Description:

Daunorubicin hydrochloride is an anthracycline antibiotic derived from the bacterium Streptomyces peucetius, primarily used in cancer therapy, particularly for treating acute myeloid leukemia and acute lymphoblastic leukemia. It exhibits a red-orange color and is known for its potent cytotoxic properties, which interfere with DNA replication and transcription by intercalating into DNA strands and inhibiting topoisomerase II. This mechanism leads to apoptosis in rapidly dividing cancer cells. Daunorubicin hydrochloride is typically administered intravenously and has a well-documented side effect profile, including cardiotoxicity, myelosuppression, and potential for secondary malignancies. Its solubility in water is enhanced by the hydrochloride salt form, making it suitable for clinical use. The compound's pharmacokinetics involve hepatic metabolism and renal excretion, and it is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. Due to its significant therapeutic benefits and associated risks, careful monitoring during treatment is essential.

Formula: C₂₇H₂₉NO₁₀·ClH

InChI: InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI key: InChIKey=GUGHGUXZJWAIAS-QQYBVWGSSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl

Synonyms:

• (1R,3R)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-D-lyxo-hexopyranoside hydrochloride
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
• Cerubidine
• Daunoblastin
• Daunomycin chlorohydrate
• Daunorubicin hydrochloride
• Daunorubicin, HCl
• Ndc 0082-4155
• Ondena
• RP 13057 hydrochloride
• Rubidomycin Hydrochloride
• Daunomycin, hydrochloride
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-

Daunorubicin Hydrochloride

CAS: 20830-81-3, 23541-50-6

Formula: C₂₇H₂₉NO₁₀·HCl

Purity: >98.0%(N)

Color and Shape: Orange to Red powder to crystal

Molecular weight: 563.98

Ref: 3B-D4532

Daunorubicin hydrochloride

CAS: 23541-50-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂₇H₃₀ClNO₁₀

Color and Shape: Powder, Orange to red

Molecular weight: 563.98

Ref: 02-J60224

DAUNORUBICIN HYDROCHLORIDE CRS

CAS: 23541-50-6

DAUNORUBICIN HYDROCHLORIDE CRS

Formula: C₂₇H₃₀ClNO₁₀

Color and Shape: Powder

Molecular weight: 563.9808

Ref: 41-D0125000

Daunorubicin Hydrochloride

CAS: 23541-50-6

Antibiotics nesoi

Formula: C₂₇H₂₉NO₁₀·HCI

Color and Shape: Red Orange Needles Crystalline Powder

Molecular weight: 667.09144

Ref: 45-1164700

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein

Formula: C₂₇H₂₉NO₁₀·HCl

Purity: 96.21% - 99.53%

Color and Shape: Cancer Drug

Molecular weight: 563.99

Ref: TM-T1511

(8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride

CAS: 23541-50-6

Formula: C₂₇H₃₀ClNO₁₀

Purity: 90%

Color and Shape: Solid

Molecular weight: 563.9808

Ref: IN-DA0037I5

Daunorubicin HCl (Epirubicin EP Impurity D HCl)

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·HCl

Color and Shape: Orange Red Solid

Molecular weight: 527.53 36.46

Ref: 4Z-D-481

Daunorubicin hydrochloride, EP grade

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·HCl

Purity: ≥ 90.0% (anhydrous)

Color and Shape: Orange-red crystalline powder

Molecular weight: 563.98

Ref: 7W-GA7448

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride

Purity: ≥95%

Molecular weight: 563.99g/mol

Ref: 54-BUP15460

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride

Purity: 98%

Molecular weight: 563.9808g/mol

Ref: 54-BID0122

Daunorubicin hydrochloride

Controlled Product

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·ClH

Color and Shape: Neat

Molecular weight: 563.98

Ref: 04-C11968000

Daunorubicin Hydrochloride

Controlled Product

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·ClH

Color and Shape: Neat

Molecular weight: 563.98

Ref: 86-MM0284.00

Daunorubicin Hydrochloride

CAS: 23541-50-6

Applications Anthracycline antibiotic related to the rhodomycins. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, Z., et al.: J. Pharmacol. Experim. Ther., 327, 474 (2008), Zhao, Y., et al.: Int. J. Pharm., 379, 90 (2009), Bayne, W., et al.: J. Pharm. Sci., 98, 2540 (2009),

Formula: C₂₇H₂₉NO₁₀·ClH

Color and Shape: Red

Molecular weight: 563.98

Ref: TR-D194500

Daunorubicin HCl - Bio-X ™

CAS: 23541-50-6

Daunorubicin is an anthracycline antibiotic and antineoplastic agent that is used in the treatment of a variety of cancers such as nonlymphocytic leukemia and acute lymphocytic leukemia. The drug binds to DNA and inhibits transcription by intercalating between DNA base pairs and affecting the activity of the topoisomerase II enzyme and thus the gene expression. This results in apoptosis, mitochondrial injury, and finally cell death.

Formula: C₂₇H₂₉NO₁₀•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 563.98 g/mol

Ref: 3D-BD164356

Daunorubicin HCl

CAS: 23541-50-6

Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription since it intercalates between the base pairs of nucleic acids. It also inhibits the topoisomerase II, proteasome and generates free radicals, which leads to cell death of treated cells. Moreover, daunorubicin triggers apoptosis trough the stimulation of ceramide synthesis. It has been used as chemotherapy agent for the treatment of myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).

Formula: C₂₇H₂₉NO₁₀·HCl

Purity: Min. 95%

Color and Shape: Red Powder

Molecular weight: 563.98 g/mol

Ref: 3D-MD11679

Doxorubicin EP Impurity A

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀HCl

Molecular weight: 527.5 : 36.46

Ref: ST-EA-CP-D102001

Epirubicin EP Impurity D

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀HCl

Molecular weight: 527.53 : 36.46

Ref: ST-EA-CP-E117004