CAS 23541-50-6
:Daunorubicin hydrochloride
Description:
Daunorubicin hydrochloride is an anthracycline antibiotic derived from the bacterium Streptomyces peucetius, primarily used in cancer therapy, particularly for treating acute myeloid leukemia and acute lymphoblastic leukemia. It exhibits a red-orange color and is known for its potent cytotoxic properties, which interfere with DNA replication and transcription by intercalating into DNA strands and inhibiting topoisomerase II. This mechanism leads to apoptosis in rapidly dividing cancer cells. Daunorubicin hydrochloride is typically administered intravenously and has a well-documented side effect profile, including cardiotoxicity, myelosuppression, and potential for secondary malignancies. Its solubility in water is enhanced by the hydrochloride salt form, making it suitable for clinical use. The compound's pharmacokinetics involve hepatic metabolism and renal excretion, and it is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. Due to its significant therapeutic benefits and associated risks, careful monitoring during treatment is essential.
Formula:C27H29NO10·ClH
InChI:InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key:InChIKey=GUGHGUXZJWAIAS-QQYBVWGSSA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Synonyms:- (1R,3R)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-D-lyxo-hexopyranoside hydrochloride
- (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride
- 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
- Cerubidine
- Daunoblastin
- Daunomycin chlorohydrate
- Daunorubicin hydrochloride
- Daunorubicin, HCl
- Ndc 0082-4155
- Ondena
- RP 13057 hydrochloride
- Rubidomycin Hydrochloride
- Daunomycin, hydrochloride
- 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
- 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- See more synonyms
Filter by
Purity percentage
0
100
|
0
|
50
|
90
|
95
|
100
- Lower prices
- Higher prices
- Lower purities
- Higher purities
- Faster estimated delivery
Daunorubicin Hydrochloride
CAS:Formula:C27H29NO10·HClPurity:>98.0%(N)Color and Shape:Orange to Red powder to crystalMolecular weight:563.98Daunorubicin hydrochloride
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo SciFormula:C27H30ClNO10Color and Shape:Powder, Orange to redMolecular weight:563.98DAUNORUBICIN HYDROCHLORIDE CRS
CAS:DAUNORUBICIN HYDROCHLORIDE CRSFormula:C27H30ClNO10Color and Shape:PowderMolecular weight:563.9808Daunorubicin Hydrochloride
CAS:Antibiotics nesoiFormula:C27H29NO10·HCIColor and Shape:Red Orange Needles Crystalline PowderMolecular weight:667.09144Daunorubicin hydrochloride
CAS:Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and proteinFormula:C27H29NO10·HClPurity:96.21% - 99.53%Color and Shape:Red SolidMolecular weight:563.99Daunorubicin hydrochloride
CAS:Daunorubicin hydrochlorideFormula:C27H29NO10·ClHPurity:>98%Color and Shape:SolidMolecular weight:563.9808Daunorubicin HCl (Epirubicin EP Impurity D HCl)
CAS:Formula:C27H29NO10·HClColor and Shape:Orange Red SolidMolecular weight:527.53 36.46Daunorubicin hydrochloride, EP grade
CAS:Formula:C27H29NO10·HClPurity:≥ 90.0% (anhydrous)Color and Shape:Orange-red crystalline powderMolecular weight:563.98Daunorubicin hydrochloride
CAS:Daunorubicin hydrochlorideFormula:C27H29NO10·HClPurity:99.5%Color and Shape:SolidMolecular weight:563.99Daunorubicin hydrochloride
CAS:Controlled ProductFormula:C27H29NO10·ClHColor and Shape:NeatMolecular weight:563.98Daunorubicin Hydrochloride
CAS:Controlled ProductFormula:C27H29NO10·ClHColor and Shape:NeatMolecular weight:563.98Daunorubicin Hydrochloride
CAS:Applications Anthracycline antibiotic related to the rhodomycins. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, Z., et al.: J. Pharmacol. Experim. Ther., 327, 474 (2008), Zhao, Y., et al.: Int. J. Pharm., 379, 90 (2009), Bayne, W., et al.: J. Pharm. Sci., 98, 2540 (2009),Formula:C27H29NO10·ClHColor and Shape:NeatMolecular weight:563.98(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
CAS:(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochlorideFormula:C27H30ClNO10Purity:98%Molecular weight:563.98Daunorubicin HCl - Bio-X ™
CAS:Daunorubicin is an anthracycline antibiotic and antineoplastic agent that is used in the treatment of a variety of cancers such as nonlymphocytic leukemia and acute lymphocytic leukemia. The drug binds to DNA and inhibits transcription by intercalating between DNA base pairs and affecting the activity of the topoisomerase II enzyme and thus the gene expression. This results in apoptosis, mitochondrial injury, and finally cell death.Formula:C27H29NO10•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:563.98 g/molDaunorubicin HCl
CAS:Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription since it intercalates between the base pairs of nucleic acids. It also inhibits the topoisomerase II, proteasome and generates free radicals, which leads to cell death of treated cells. Moreover, daunorubicin triggers apoptosis trough the stimulation of ceramide synthesis. It has been used as chemotherapy agent for the treatment of myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).Formula:C27H29NO10·HClPurity:Min. 95%Color and Shape:Red PowderMolecular weight:563.98 g/mol
