CAS 2366237-37-6

Formula: C25H31FN8

InChI: InChI=1S/C25H31FN8/c1-3-32-13-25(14-32)15-33(16-25)18-7-8-21(27-10-18)30-24-28-12-20(26)22(31-24)19-11-29-34-9-5-4-6-17(2)23(19)34/h7-8,10-12,17H,3-6,9,13-16H2,1-2H3,(H,27,28,30,31)/t17-/m1/s1

InChI key: KMRYRPPWJDYHAL-QGZVFWFLSA-N

SMILES: CCN1CC2(C1)CN(C2)C3=CN=C(C=C3)NC4=NC=C(C(=N4)C5=C6[C@@H](CCCCN6N=C5)C)F

CDK4/6-IN-3

CAS: 2366237-37-6

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.

Formula: C₂₅H₃₁FN₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 462.57

Ref: TM-T10737