CAS 23720-80-1
:Nardosinone
Description:
Nardosinone is a natural sesquiterpene compound primarily derived from the plant Nardostachys jatamansi, commonly known as spikenard. It is characterized by its complex bicyclic structure, which contributes to its unique chemical properties. Nardosinone exhibits a range of biological activities, including anti-inflammatory, antimicrobial, and potential neuroprotective effects, making it of interest in pharmacological research. The compound is typically found in essential oils and extracts from the plant, and its presence is often associated with traditional medicinal practices. In terms of solubility, nardosinone is generally more soluble in organic solvents than in water, which is common for many terpenoids. Its molecular structure includes multiple functional groups that can participate in various chemical reactions, enhancing its potential applications in both natural product chemistry and therapeutic development. Overall, nardosinone represents a significant compound within the realm of natural products, with ongoing studies aimed at elucidating its full range of biological effects and potential uses in medicine.
Formula:C15H22O3
InChI:InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1
InChI key:InChIKey=KXGHHSIMRWPVQM-JWFUOXDNSA-N
SMILES:C[C@@]12[C@]3([C@@](CC(=O)C1=CCC[C@H]2C)(OOC3(C)C)[H])[H]
Synonyms:- (3aR,9R,9aR,9bS)-1,1,9,9a-tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one
- (3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, [3aR-(3aα,9α,9aα,9bα)]-
- Nardosinon
- Nardosinone
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(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS:Formula:C15H22O3Purity:99%Color and Shape:SolidMolecular weight:250.3334Nardosinone
CAS:Nardosinone is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. It has a wide spectrum of targets including PI3K,Akt,MEK,ERK, PKA, MAPK.Formula:C15H22O3Purity:95%~99%Molecular weight:250.338Nardosinone (Standard)
CAS:Nardosinone (Standard) is a reference standard for research and analysis in studies involving Nardosinone. 1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. 4. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.Formula:C15H22O3Molecular weight:250.3334Nardosinone
CAS:Controlled ProductApplications Nardosinone reduces neuronal injury and protects H9c2 cardiac cells from angiotensin II-induced hypertrophy which may give rise to heart failure. Enhancer of nerve growth factor (NGF).
References Du, M. et al.: J. Huazhong Uni. Sci. Tech. Med. Serv., 33, 822 (2013); Li, P. et al.: Dev. Brain Res., 145, 177 (2003);Formula:C15H22O3Color and Shape:NeatMolecular weight:250.33(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS:Formula:C15H22O3Purity:99%Molecular weight:250.33Nardosinone
CAS:Nardosinone inhibits H9c2 cell hypertrophy, protects neurons from OGD, and boosts neurite outgrowth by modifying key signaling pathways.Formula:C15H22O3Purity:98.82% - 99%Color and Shape:SolidMolecular weight:250.3334Nardosinone
CAS:Oxygen-heterocyclic compoundFormula:C15H22O3Purity:≥ 98.0 % (HPLC)Color and Shape:CrystalsMolecular weight:250.34Nardosinone
CAS:Controlled ProductNardosinone is a secoiridoid compound, which is a natural product derived from the roots of the plant Nardostachys jatamansi, commonly known as spikenard. The source of Nardosinone is a flowering plant that is native to the Himalayan region and has been traditionally used in Ayurvedic medicine for its therapeutic properties. The mode of action of Nardosinone involves modulation of neurotransmitter systems, inhibition of neuroinflammation, and protection against oxidative damage, contributing to its neuroprotective effects. Nardosinone exhibits potential applications in the treatment of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, due to its ability to improve cognitive function and mitigate neuronal damage. Additionally, it is being investigated for its potential role in mood regulation and anti-anxiety effects. Given its intriguing pharmacological profile, Nardosinone is the subject of ongoing research aimed at understanding its comprehensive mechanisms and potential therapeutic benefits in neuroscience.Formula:C15H22O3Purity:Min. 95%Color and Shape:SolidMolecular weight:250.33 g/mol
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