CAS 2378606-21-2

OPBP-1

CAS: 2378606-21-2

OPBP-1 is a D-peptide identified through phage display screening, molecular docking, and molecular dynamics simulation. It possesses high stability, strong oral bioavailability, and significant antitumor activity. Its mechanism of action involves selectively binding to PD-L1, thereby effectively disrupting the PD-1/PD-L1 interaction. This disruption restores T cell function and downregulates the proportion of myeloid-derived suppressor cells (MDSCs), counteracting immune escape. Therefore, OPBP-1 is a candidate molecule for cancer immunotherapy research.

Formula: C₆₄H₉₂N₂₀O₁₉S

Molecular weight: 1477.62

Ref: TM-TP3626