CAS 2396639-29-3

Formula: C24H19ClFN3O2

InChI: InChI=1S/C24H19ClFN3O2/c1-11(2)19-21(20-14-6-8-27-17(14)4-3-16(20)25)23(24(30)31)29-22(19)15-9-12(26)10-18-13(15)5-7-28-18/h3-11,27-29H,1-2H3,(H,30,31)

InChI key: CWMDJTCNUCJTSW-UHFFFAOYSA-N

SMILES: CC(C)C1=C(NC(=C1C2=C(C=CC3=C2C=CN3)Cl)C(=O)O)C4=C5C=CNC5=CC(=C4)F

PRC1-IN-1

CAS: 2396639-29-3

PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.

Formula: C₂₄H₁₉ClFN₃O₂

Color and Shape: Solid

Molecular weight: 435.878

Ref: TM-T205306