CAS 23981-80-8

(±)-Naproxen

Description:

(±)-Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever. It belongs to the propionic acid class of NSAIDs and is characterized by its ability to inhibit cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins involved in inflammation and pain signaling. The substance is a racemic mixture, meaning it contains equal parts of its two enantiomers, which can exhibit different pharmacological effects. (±)-Naproxen is typically administered in its sodium salt form for enhanced solubility and absorption. It has a relatively long half-life, allowing for twice-daily dosing in therapeutic applications. Common side effects may include gastrointestinal discomfort, headache, and dizziness, while more serious risks involve cardiovascular and gastrointestinal complications. The compound is also known for its anti-inflammatory properties, making it effective in treating conditions such as arthritis and tendinitis. Its chemical structure includes a naphthalene ring, contributing to its lipophilicity and overall pharmacokinetic profile.

Formula: C₁₄H₁₄O₃

InChI: InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)

InChI key: InChIKey=CMWTZPSULFXXJA-UHFFFAOYSA-N

SMILES: C(C(O)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1

Synonyms:

• (RS)-Naproxen
• (±)-2-(6-Methoxy-2-naphthalenyl)propionic acid
• (±)-6-Methoxy-α-methyl-2-naphthaleneacetic acid
• (±)-Naproxen
• 2-(6-Methoxy-2-naphthyl)propanoic acid
• 2-(6-Methoxynaphthalen-2-yl)propanoic acid
• 2-(6-Methoxynaphthalen-2-yl)propionic acid
• 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-
• 6-Methoxy-2-naphthyl-α-methylacetic acid
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-2-(6-Methoxy-2-naphthyl)propionic acid
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Naproxen
• DL-Naproxen
• Racemic Naproxen
• α-(6-Methoxy-2-naphthyl)propionic acid

(+/-)-Naproxen

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Purity: >98.0%(GC)(T)

Color and Shape: White to Light red to Green powder to crystal

Molecular weight: 230.26

Ref: 3B-M1220

NAPROXEN (RACEMIC) CRS

CAS: 23981-80-8

NAPROXEN (RACEMIC) CRS

Formula: C₁₄H₁₄O₃

Molecular weight: 230.2592

Ref: 41-Y0000399

rac-Naproxen

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Molecular weight: 230.26

Ref: 4Z-N-2339

2-(6-Methoxynaphthalen-2-Yl)Propanoic Acid

CAS: 23981-80-8

2-(6-Methoxynaphthalen-2-Yl)Propanoic Acid

Formula: C₁₄H₁₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 230.26

Ref: 54-OR1009794

(+/-)-Naproxen-d3 (α-methyl-d3)

CAS: 23981-80-8, 958293-77-1

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 233.28

Ref: 3U-D6523

rac-Naproxen

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Color and Shape: White To Light Beige

Molecular weight: 230.26

Ref: 61-FOR0152.19

rac-Naproxen

Controlled Product

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Color and Shape: Neat

Molecular weight: 230.26

Ref: 86-MM0152.19

2-(6-Methoxynaphthalen-2-Yl)Propanoic Acid

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 230.2592

Ref: IN-DA00BBNZ

rac-Naproxen

CAS: 23981-80-8

Applications An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)

Formula: C₁₄H₁₄O₃

Color and Shape: Neat

Molecular weight: 230.26

Ref: TR-N377526

Naproxen racemate

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Molecular weight: 230.26

Ref: ST-EA-CP-N2018

Racemic Naproxen

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Molecular weight: 230.26

Ref: BE-RMCN029033

2-(6-Methoxy-2-naphthyl)propionic acid

CAS: 23981-80-8

Formula: C₁₄H₁₄O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 230.263

Ref: 10-F066541

(±)-Naproxen

CAS: 23981-80-8

2-(6-Methoxynaphthalen-2-yl)propanoic acid

Formula: C₁₄H₁₄O₃

Purity: 98%

Molecular weight: 230.26

Ref: IN-DG15383

rac-Naproxen-13C3

Controlled Product

CAS: 23981-80-8

Formula: C₃C₁₁H₁₄O₃

Color and Shape: Neat

Molecular weight: 233.237

Ref: TR-N377529

rac-Naproxen

CAS: 23981-80-8

Naproxen is a non-steroidal anti-inflammatory drug that is used to treat pain, fever, and inflammation. It is an analgesic and antipyretic agent. Naproxen has been shown to have a high affinity for copper chloride, which may be due to the formation of an amide bond. The reaction mechanism of naproxen's inhibition of prostaglandin synthesis in bacteria has been investigated using x-ray diffraction data from bacterial strains and human serum. Naproxen also has inhibitory properties on the reaction solution in vitro and enhances the toxicity studies with isooctane in vivo.

Formula: C₁₄H₁₄O₃

Purity: (%) Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 230.26 g/mol

Ref: 3D-FN27551