CAS 2414373-42-3

Formula: C19H16N6O

InChI: InChI=1S/C19H16N6O/c20-18(26)15-3-1-14(2-4-15)16-12-23-25-10-7-17(24-19(16)25)22-11-13-5-8-21-9-6-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)

InChI key: DICBAYNNPUCOOQ-UHFFFAOYSA-N

SMILES: C1=CC(=CC=C1C2=C3N=C(C=CN3N=C2)NCC4=CC=NC=C4)C(=O)N

4-(5-((Pyridin-4-ylmethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)benzamide

CAS: 2414373-42-3

Purity: 95%

Ref: IN-DA01X7N5

DUN73423

CAS: 2414373-42-3

DUN73423

Formula: C₁₉H₁₆N₆O

Purity: ≥98%

Molecular weight: 344.37

Ref: 54-BUP07954

4-5-(4-Pyridylmethylamino)pyrazolo1,5-apyrimidin-3-ylbenzamide

CAS: 2414373-42-3

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 344.37 g/mol

Ref: 3D-EP176312

DUN73423

CAS: 2414373-42-3

DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.

Formula: C₁₉H₁₆N₆O

Purity: 98.03%

Color and Shape: Solid

Molecular weight: 344.37

Ref: TM-T69644