CAS 241479-67-4: Isavuconazole

Description: Isavuconazole is a triazole antifungal agent used primarily for the treatment of invasive fungal infections, particularly those caused by Aspergillus and Candida species. It functions by inhibiting the enzyme lanosterol 14α-demethylase, which is crucial for ergosterol synthesis in fungal cell membranes, thereby disrupting their integrity and function. Isavuconazole is characterized by its broad-spectrum antifungal activity, favorable pharmacokinetic profile, and the ability to be administered orally or intravenously. It has a relatively long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound is also notable for its solubility and stability, which contribute to its efficacy. Additionally, isavuconazole has a unique mechanism of action compared to other azole antifungals, as it is a prodrug that is converted into its active form in the body. Its safety profile includes potential side effects such as liver enzyme elevations and interactions with other medications, necessitating careful monitoring during treatment. Overall, isavuconazole represents an important advancement in antifungal therapy.

Formula: C₂₂H₁₇F₂N₅OS

InChI: InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1

InChI key: InChIKey=DDFOUSQFMYRUQK-RCDICMHDSA-N

SMILES: N#CC=1C=CC(=CC1)C=2N=C(SC2)C(C)C(O)(C3=CC(F)=CC=C3F)CN4N=CN=C4

Synonyms:

• (2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• 1-[(2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazole
• 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl] benzonitrile
• 4-[2-[(2R)-(2,5-Difluorophenyl)-2-hydroxy-(1R)-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thiazol-4-yl]benzonitrile
• Bal-4815
• Benzonitrile, 4-[2-[(1R,2R)-2-(2,5-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-
• Ro-0094815

Isavuconazole

CAS: 241479-67-4

• Formula: C₂₂H₁₇F₂N₅OS
• Purity: >98.0%(HPLC)(qNMR)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 437.47

Isavuconazole

CAS: 241479-67-4

• Formula: C₂₂H₁₇F₂N₅OS
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 437.4651

4-(2-((1R,2R)-1-(2,5-Difluorophenyl)-1-Hydroxy-1-(1H-1,2,4-Triazol-1-Yl)Propan-2-Yl)Thiazol-4-Yl)Benzonitrile

CAS: 241479-67-4

• Purity: 98%
• Molecular weight: 437.47g/mol

Isavuconazole

CAS: 241479-67-4

• Purity: 98%
• Molecular weight: 437.47g/mol

Isavuconazole-d4

CAS: 241479-67-4

• Formula: C₂₂H₁₃D₄F₂N₅OS
• Color and Shape: White To Off-White Solid
• Molecular weight: 441.49

Isavuconazole

CAS: 241479-67-4

• Formula: C₂₂H₁₇F₂N₅OS
• Color and Shape: White To Off-White Solid
• Molecular weight: 437.47

Isavuconazole

CAS: 241479-67-4

• Formula: C₂₂H₁₇F₂N₅OS
• Color and Shape: Neat
• Molecular weight: 437.47

Isavuconazole

CAS: 241479-67-4

Isavuconazole (RO-0094815) is an azole antifungal with MICs 0.002-0.5 mg/liter against C. albicans to C. …

• Formula: C₂₂H₁₇F₂N₅OS
• Purity: 100% - 99.97%
• Color and Shape: Solid
• Molecular weight: 437.47

Isavuconazole

CAS: 241479-67-4

Applications Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has …

• Formula: C₂₂H₁₇F₂N₅OS
• Color and Shape: White Solid
• Molecular weight: 437.47

Isavuconazole

CAS: 241479-67-4

Anti-fungal; lanosterol 14α-demethylase inhibitor

• Formula: C₂₂H₁₇F₂N₅OS
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 437.47 g/mol

(S,S)-Isavuconazole

CAS: 241479-67-4

• Formula: C₂₂H₁₇F₂N₅OS
• Color and Shape: Neat
• Molecular weight: 437.47

(2-(Methyl((1-(methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)amino)ethoxy)carbonyl)amino)pyridin-3-yl)methyl Methylglycinate

CAS: 241479-67-4

• Formula: C₂₃H₃₂N₆O₆
• Color and Shape: Neat
• Molecular weight: 488.537