CAS 241479-67-4

Isavuconazole

Description:

Isavuconazole is a triazole antifungal agent used primarily for the treatment of invasive fungal infections, particularly those caused by Aspergillus and Candida species. It functions by inhibiting the enzyme lanosterol 14α-demethylase, which is crucial for ergosterol synthesis in fungal cell membranes, thereby disrupting their integrity and function. Isavuconazole is characterized by its broad-spectrum antifungal activity, favorable pharmacokinetic profile, and the ability to be administered orally or intravenously. It has a relatively long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound is also notable for its solubility and stability, which contribute to its efficacy. Additionally, isavuconazole has a unique mechanism of action compared to other azole antifungals, as it is a prodrug that is converted into its active form in the body. Its safety profile includes potential side effects such as liver enzyme elevations and interactions with other medications, necessitating careful monitoring during treatment. Overall, isavuconazole represents an important advancement in antifungal therapy.

Formula: C₂₂H₁₇F₂N₅OS

InChI: InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1

InChI key: InChIKey=DDFOUSQFMYRUQK-RCDICMHDSA-N

SMILES: [C@@]([C@@H](C)C1=NC(=CS1)C2=CC=C(C#N)C=C2)(CN3C=NC=N3)(O)C4=C(F)C=CC(F)=C4

Synonyms:

• (2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• 1-[(2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazole
• 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl] benzonitrile
• 4-[2-[(2R)-(2,5-Difluorophenyl)-2-hydroxy-(1R)-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thiazol-4-yl]benzonitrile
• Bal-4815
• Benzonitrile, 4-[2-[(1R,2R)-2-(2,5-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-
• Ro-0094815

Isavuconazole

CAS: 241479-67-4

Formula: C₂₂H₁₇F₂N₅OS

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 437.47

Ref: 3B-I1188

4-(2-((1R,2R)-1-(2,5-Difluorophenyl)-1-Hydroxy-1-(1H-1,2,4-Triazol-1-Yl)Propan-2-Yl)Thiazol-4-Yl)Benzonitrile

CAS: 241479-67-4

4-(2-((1R,2R)-1-(2,5-Difluorophenyl)-1-Hydroxy-1-(1H-1,2,4-Triazol-1-Yl)Propan-2-Yl)Thiazol-4-Yl)Benzonitrile

Formula: C₂₂H₁₇F₂N₅OS

Purity: 98%

Molecular weight: 437.47

Ref: 54-PC108975

Isavuconazole

CAS: 241479-67-4

Formula: C₂₂H₁₇F₂N₅OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 437.4651

Ref: IN-DA00BBOF

Isavuconazole

CAS: 241479-67-4

Formula: C₂₂H₁₇F₂N₅OS

Color and Shape: White To Off-White Solid

Molecular weight: 437.47

Ref: 4Z-I-070019

Isavuconazole

CAS: 241479-67-4

Isavuconazole

Formula: C₂₂H₁₇F₂N₅OS

Purity: ≥98%

Molecular weight: 437.47

Ref: 54-BUP15219

Isavuconazole-d4

CAS: 241479-67-4

Formula: C₂₂H₁₃D₄F₂N₅OS

Color and Shape: White To Off-White Solid

Molecular weight: 441.49

Ref: 4Z-I-070001

Isavuconazole

Controlled Product

CAS: 241479-67-4

Formula: C₂₂H₁₇F₂N₅OS

Color and Shape: Neat

Molecular weight: 437.47

Ref: 86-MM3613.01

Isavuconazole

CAS: 241479-67-4

4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile

Formula: C₂₂H₁₇F₂N₅OS

Purity: 98%

Molecular weight: 437.47

Ref: IN-DG305705

Isavuconazole

CAS: 241479-67-4

Isavuconazole (RO-0094815) is an azole antifungal with MICs 0.002-0.5 mg/liter against C. albicans to C. glabrata.

Formula: C₂₂H₁₇F₂N₅OS

Purity: 99.74% - >99.99%

Color and Shape: Solid

Molecular weight: 437.47

Ref: TM-T2305

Isavuconazole

CAS: 241479-67-4

Formula: C₂₂H₁₇F₂N₅OS

Molecular weight: 437.47

Ref: ST-EA-CP-I33004

Isavuconazole

Controlled Product

CAS: 241479-67-4

Applications Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida spp., the Zygomycetes and Cryptococcus spp.
References Ohwada, J., et al.: Bioorg. Med. Chem. Lett., 13, 191 (2003), Guinea, J., et al.: Antimicrob. Agents Chemother., 52, 1396 (2008)

Formula: C₂₂H₁₇F₂N₅OS

Color and Shape: Neat

Molecular weight: 437.47

Ref: TR-I777830

Isavuconazole

CAS: 241479-67-4

Anti-fungal; lanosterol 14α-demethylase inhibitor

Formula: C₂₂H₁₇F₂N₅OS

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 437.47 g/mol

Ref: 3D-FI24654

Isavuconazole

CAS: 241479-67-4

Ref: BE-RMCI109000

Isavuconazole-[13C, d4]

CAS: 241479-67-4

Ref: BE-MCD-7753

Isavuconazole

CAS: 241479-67-4

Ref: BE-MU-7753

ISAVUCONAZOLE

CAS: 241479-67-4

Purity: 98%

Molecular weight: 437.4700012

Ref: 10-F828503

(2-(Methyl((1-(methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)amino)ethoxy)carbonyl)amino)pyridin-3-yl)methyl methylglycinate

Controlled Product

CAS: 241479-67-4

Formula: C₂₃H₃₂N₆O₆

Color and Shape: Neat

Molecular weight: 488.537

Ref: TR-M510555