CAS 24305-27-9

TSH-releasing hormone

Description:

Thyrotropin-releasing hormone (TRH), also known as TSH-releasing hormone, is a tripeptide hormone composed of three amino acids: pyroglutamic acid, histidine, and proline. It plays a crucial role in the regulation of thyroid function by stimulating the release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. TRH is synthesized in the hypothalamus and is involved in the hypothalamic-pituitary-thyroid axis, influencing metabolic processes and energy homeostasis. The CAS number 24305-27-9 specifically identifies this peptide, which is typically found in a solid or lyophilized form for research and therapeutic applications. TRH is water-soluble and can be administered via various routes, including intravenous or subcutaneous injection. Its biological activity is mediated through specific receptors in the pituitary gland, leading to downstream effects on thyroid hormone production. Additionally, TRH has been studied for its potential roles in various physiological and pathological conditions, including its effects on mood and stress responses.

Formula: C₁₆H₂₂N₆O₄

InChI: InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1

InChI key: InChIKey=XNSAINXGIQZQOO-SRVKXCTJSA-N

SMILES: C([C@H](CC1=CN=CN1)NC(=O)[C@@H]2CCC(=O)N2)(=O)N3[C@H](C(N)=O)CCC3

Synonyms:

• (Pyro)-<span class="text-smallcaps">L</smallcap>-glutamic acid-<smallcap>L</smallcap>-histidine-<smallcap>L</span>-proline-NH₂
• (Pyro)-L-glutamic acid-L-histidine-L-proline-NH2
• 252: PN: WO2010033207 SEQID: 378 claimed protein
• 5-Oxo-<span class="text-smallcaps">L</smallcap>-prolyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
• 83: PN: US20090175821 PAGE: 403 claimed protein
• <span class="text-smallcaps">L</smallcap>-Prolinamide, 5-oxo-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-histidyl-
• <span class="text-smallcaps">L</smallcap>-Pyroglutamyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
• <span class="text-smallcaps">L</smallcap>-Pyroglutamyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-proline amide
• Abbott 38579
• Antepan
• Fda 1725
• L-Pyroglutamyl-L-histidyl-L-prolinamide
• L-Pyroglutamyl-L-histidyl-L-proline amide
• Lopremone
• Prem
• Protirelin
• Protirelina
• Protireline
• Relefact TRH
• Rifathyroin
• Rifotironin
• Ro 8-6270/9
• Stimu TSH
• Synthetic TRF
• Synthetic TRH
• Synthetic TSH-releasing factor
• Synthetic TSH-releasing hormone
• Synthetic thyrotropin-releasing factor
• Synthetic thyrotropin-releasing hormone
• TRF
• TRH
• TSH-releasing factor
• TSH-releasing hormone
• Thypinone
• Thyrefact
• Thyroid releasing hormone
• Thyroid-stimulating hormone-releasing factor
• Thyroliberin
• Thyrotropic hormone-releasing factor
• Thyrotropic hormone-releasing hormone
• Thyrotropic releasing hormone
• Thyrotropic-releasing factor
• Thyrotropin-releasing factor
• Thyrotropin-releasing hormone
• Tsh-Rf
• L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-

Thyrotropin-Releasing Hormone

CAS: 24305-27-9

Thyrotropin-Releasing Hormone

Formula: C₁₆H₂₂N₆O₄

Color and Shape: White, Lyophilized powder

Molecular weight: 362.38

Ref: 02-J62120

TRH

CAS: 24305-27-9

TRH exhibits a variety of biological effects, when injected into humans or animals. Its physiological role appears to be the stimulation of thyrotropin (TSH) and prolactin (PRL) release from the anterior pituitary. Though it was first identified in the hypothalamus as a regulator of the pituitary-thyroid axis, TRH was detected as well by Luo et al. in pancreatic β-cells co-localized with insulin. Application of the hormone reverted hyperglycemia in rats. Moreover, TRH plays an important role in the control of human hair-growth and hair follicle pigmentation.

Formula: C₁₆H₂₂N₆O₄

Purity: 98.6%

Color and Shape: Whitish Powder

Molecular weight: 362.39

Ref: 01-4038214

PROTIRELIN CRS

CAS: 24305-27-9

PROTIRELIN CRS

Formula: C₁₆H₂₂N₆O₄

Molecular weight: 362.3837

Ref: 41-P3760000

Protirelin

CAS: 24305-27-9

Protirelin

Purity: ≥98%

Molecular weight: 362.38g/mol

Ref: 54-BUP06401

L-Pyroglutamyl-L-Histidyl-L-Prolinamide

CAS: 24305-27-9

L-Pyroglutamyl-L-Histidyl-L-Prolinamide

Purity: 98%

Molecular weight: 362.38g/mol

Ref: 54-OR1026190

Thyrotropin releasing hormone

CAS: 24305-27-9

Formula: C₁₆H₂₂N₆O₄

Molecular weight: 362.38

Ref: 7W-GL4561

Protirelin

CAS: 24305-27-9

Formula: C₁₆H₂₂N₆O₄

Molecular weight: 362.39

Ref: 4Z-PP-357001

Protirelin

CAS: 24305-27-9

Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.

Formula: C₁₆H₂₂N₆O₄

Purity: 99.76%

Color and Shape: White Or Almost White Powder

Molecular weight: 362.38

Ref: TM-T6956

Protirelin

CAS: 24305-27-9

Color and Shape: Neat

Ref: 86-MM3358.00

Protirelin

CAS: 24305-27-9

Formula: C₁₆H₂₂N₆O₄

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 362.38

Ref: BP-BPPG055

Thyrotropin-Releasing Hormone

Controlled Product

CAS: 24305-27-9

Applications Thyrotropin-Releasing Hormone is a hypothalamic hypophysiotropic neuropeptide, which has the ability to stimulate the release of thyroid-stimulating hormone in mammals. It is proven that Thyrotropin-Releasing Hormone can be used to accelerate wound healing.
References Kanasaki, H., et al.: Neuropeptides., 54, 73 (2015); Nie, C., et al.: J. Surg. Res., 189, 364 (2014);

Formula: C₁₆H₂₂N₆O₄

Color and Shape: Off-White

Molecular weight: 362.38

Ref: TR-T413510

L-Pyroglutamyl-L-histidyl-L-prolinamide

CAS: 24305-27-9

L-Pyroglutamyl-L-histidyl-L-prolinamide (PGC) is a pyrrolidine that is used for the treatment of neurologic disorders. It has been shown to be effective in treating depression and a number of other neurologic disorders, including Parkinson's disease, Alzheimer's disease, and epilepsy. PGC has also been shown to have an antidepressant effect in women with depression who are pregnant or have recently given birth. In addition, it has been found to be clinically effective in the treatment of symptoms associated with Parkinson’s Disease. PGC is not absorbed into the bloodstream and must be injected directly into muscle tissue or fat cells in order to produce its therapeutic effects.

Formula: C₁₆H₂₂N₆O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 362.38 g/mol

Ref: 3D-FP33965

Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)

CAS: 24305-27-9

Thyrotropin releasing hormone (TRH) is a peptide that is produced in the hypothalamus. It has various functions, including being an activator of thyroid stimulating hormone (TSH) and releasing growth hormone from the anterior pituitary gland. TRH also has anti-inflammatory effects and is used as a research tool in cell biology. TRH binds to receptors on cells and can activate ion channels, which causes an influx of calcium ions into cells. This leads to the activation of protein kinases, which are important in cell signaling pathways. TRH also interacts with other proteins, such as receptor tyrosine kinases and G-protein coupled receptors.

Formula: C₁₆H₂₂N₆O₄

Purity: Min. 95%

Molecular weight: 362.38 g/mol

Ref: 3D-PTR-4011-V

Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)

CAS: 24305-27-9

Thyrotropin Releasing Hormone (TRH) is a hormone that stimulates the release of thyroid hormones. TRH has been used to diagnose and treat conditions such as autoimmune diseases, infectious diseases, and thyroid disease. It is also used in the treatment of patients with hypothyroidism who are not responding to levothyroxine therapy. TRH is administered intravenously or intramuscularly. This drug is primarily used for diagnostic purposes in women who have symptoms of hyperthyroidism but normal serum levels of TSH and thyroxine levels. TRH administration can result in a rise in serum prolactin levels, which may be useful for diagnosis of the condition hyperprolactinemia.

Formula: C₁₆H₂₂N₆O₄•H₂O

Purity: Min. 95%

Molecular weight: 380.4 g/mol

Ref: 3D-PTR-4011