CAS 24390-14-5

Doxycycline hyclate

Description:

Doxycycline hyclate is a broad-spectrum antibiotic belonging to the tetracycline class, primarily used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, and certain skin conditions. It is characterized by its ability to inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit, thereby preventing the growth and reproduction of the microorganisms. Doxycycline hyclate is a semi-synthetic derivative of tetracycline, which enhances its stability and absorption in the gastrointestinal tract. The substance is typically administered orally and is known for its relatively long half-life, allowing for once or twice daily dosing. It is also effective against certain protozoal infections and is used in the treatment of acne and as prophylaxis for malaria. Common side effects may include gastrointestinal disturbances, photosensitivity, and potential effects on bone and teeth development in children. Due to its broad activity, doxycycline hyclate is a valuable tool in both human and veterinary medicine.

Formula: C₂₂H₂₄N₂O₈C₂H₆O·ClHH₂O

InChI: InChI=1S/C22H24N2O8.C2H6O.ClH.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;1H;1H2/t7-,10+,14+,15-,17-,22-;;;/m0.../s1

InChI key: InChIKey=JRNIHERUNQWMMW-WBYAVNBMSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@@H]3C)=CC=CC4O)[H])[H].Cl.C(C)O.O

Synonyms:

• (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride
• (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione - ethanol (2:1) dihydrochloride hydrate
• (2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
• (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione - ethanol (2:1) dihydrochloride hydrate
• (4S,4Ar,5S,5Ar,6R,12As)-4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide Hydrochloride
• (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide-ethanol hydrochloride hydrate (2:1:2:1)
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1)
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol (2:1), monohydrate
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5α,5aα,6α,12aα)]-, compd. with ethanol (2:1), monohydrate
• 2-Naphthacenecarboxamide, 4β-(dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,5β,10,12,12aβ-pentahydroxy-6β-methyl-1,11-dioxo-, monohydrochloride, compd. with ethyl alc. (2:1), monohydrate
• 4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Na
• 4-(Dimethylamino)-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide
• 4-(Dimethylamino)-3,5,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide-Ethanol (2:1) Dihydrochloride Hydrate
• 6-Desoxy-5-hydroxytetracycline hydrochloride hemihydrate hemiethanolate
• Atridox
• BioPure MTAD
• Doryx
• Dox-T 100
• Doxitrat
• Doxy 100
• Doxycycline Hyclate
• Doxycycline Hyclate Monohydrate
• Doxycycline Hydrate
• Doxycycline Hydrochlocide
• Doxycycline Hydrochloride
• Doxycycline Hydrochloride Anhydrous
• Doxycycline Hydrochloride Hemiethanolate Hemihydrate
• Doxycycline hyclate COS
• Doxyprex
• Ethanol, compd. with (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (1:2), monohydrate
• Ethanol, compd. with [4S-(4α,4aα,5α,5aα,6α,12aα)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (1:2), monohydrate
• Monodoks
• Periostat
• Tetraclean

Doxycycline Hyclate

CAS: 10592-13-9, 24390-14-5, 564-25-0

Formula: C₂₂H₂₄N₂O₈C₂H₆O·HClH₂O

Purity: >97.0%(HPLC)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 512.94

Ref: 3B-D4116

Doxycycline hyclate

CAS: 24390-14-5

Doxycycline hyclate, 24390-14-5, is an antibiotic which inhibits bacterial growth by preventing polypeptide formation. Learn more at Thermo Fisher Scientific.

Formula: C₄₆H₅₈Cl₂N₄O₁₈

Color and Shape: Powder or crystals or crystalline powder, Yellow

Molecular weight: 1025.88

Ref: 02-J60579

DOXYCYCLINE FOR SYSTEM SUITABILITY CRS

CAS: 24390-14-5

DOXYCYCLINE FOR SYSTEM SUITABILITY CRS

Formula: C₄₆H₅₈Cl₂N₄O₁₈

Color and Shape: Crystalline Powder. Yellow. Powder.

Molecular weight: 1025.875

Ref: 41-Y0001714

DOXYCYCLINE HYCLATE CRS

CAS: 24390-14-5

DOXYCYCLINE HYCLATE CRS

Formula: C₄₆H₅₈Cl₂N₄O₁₈

Color and Shape: Crystalline Powder. Yellow. Powder.

Molecular weight: 1025.875

Ref: 41-D3000000

Doxycycline hyclate

CAS: 24390-14-5

Doxycycline hyclate

Formula: C₂₂H₂₄N₂O₈ / C₂₂H₂₅ClN₂O₈

Purity: 83.1% / 89.9%

Color and Shape: Yellow

Molecular weight: 444.15327 / 480.12994

Ref: 47-780

Doxycycline Hyclate

CAS: 24390-14-5

Tetracyclines and their derivatives; salts thereof

Formula: C₁₂H₂₄N₂O₈C₂H₆O·ClHH₂O

Color and Shape: Light Yellow Powder

Molecular weight: 1025.89

Ref: 45-1226003

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1)

CAS: 24390-14-5

Formula: C₄₆H₅₈Cl₂N₄O₁₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 1025.8747

Ref: IN-DA0034T4

Doxycycline hyclate

CAS: 24390-14-5

Formula: C₂₂H₂₄N₂O₈·HCl·5H₂O·5C₂H₆O

Purity: 95.0 - 102.0 % (C22H25ClN2O8, anhydrous and ethanol free basis)

Color and Shape: Yellow, crystalline powder, hygroscopic

Molecular weight: 512.94

Ref: 7W-GA1726

Doxycycline (hyclate)

CAS: 24390-14-5

Doxycycline (hyclate)

Purity: ≥95%

Molecular weight: 512.9g/mol

Ref: 54-BUP17418

Doxycycline hyclate

CAS: 24390-14-5

Doxycycline hyclate

Purity: 99%

Molecular weight: 544.982g/mol

Ref: 54-BI12151

Doxycycline Hyclate

CAS: 24390-14-5

Color and Shape: Neat

Ref: 61-FOR0276.00

Doxycycline hyclate 100 µg/mL in Acetonitrile

CAS: 24390-14-5

Formula: C₂₂H₂₄N₂O₈·C₂H₆OClH·H₂O

Color and Shape: Single Solution

Molecular weight: 1025.87

Ref: 04-A13084280AL-100

Doxycycline hyclate

Controlled Product

CAS: 24390-14-5

Formula: C₂₂H₂₄N₂O₈·C₂H₆OClH·H₂O

Color and Shape: Neat

Molecular weight: 1025.87

Ref: 04-C13084280

PharmaVetResiMix 5 Tetracyclines-v10 10 µg/mL in Methanol

Controlled Product

CAS: 101342-45-4, 14206-58-7, 179471-95-5, 2058-46-0, 23313-80-6, 24390-14-5, 41411-66-9, 64-72-2, 64-73-3, 64-75-5

Color and Shape: Mixture

Ref: 04-A30000035ME

Doxycycline Hyclate

Controlled Product

CAS: 24390-14-5

Formula: C₂₂H₂₄N₂O₈·C₂H₆OClH·H₂O

Color and Shape: Neat

Molecular weight: 1025.87

Ref: 86-MM0276.00

Doxycycline (hyclate)

CAS: 24390-14-5

Doxycycline hyclate (WC2031) is a synthetic tetracycline derivative with similar antimicrobial activity. Doxycycline hyclate is also an inhibitor of MMP.

Formula: C₂₂H₂₄N₂O₈·HClC₂H₆OH₂O

Purity: 97.48% - >99.99%

Color and Shape: Yellow Crystallien Powder

Molecular weight: 512.90

Ref: TM-T1687L

Doxycycline Hyclate

Controlled Product

CAS: 24390-14-5

Applications Antibacterial.
References Fabre, et al.: Chemotherapia, 11, 73 (1966), Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Polson, A.M., et al.: J. Periodontol., 68, 110 (1997),

Formula: C₂₂H₂₄N₂O₈·C₂H₆O·2ClH·H₂O

Color and Shape: Yellow

Molecular weight: 1025.87

Ref: TR-D561500

Doxycycline Hyclate

CAS: 24390-14-5

Formula: C₂₂H₂₄N₂O₈·C₂H₆O·2ClH·H₂O

Ref: TR-TRC-D561500

Doxycycline Hyclate

CAS: 24390-14-5

Formula: C₂₂H₂₄N₂O₈(C₂H₆O)HCl(H₂O)

Molecular weight: 444.44 : 1/2(46.07) : 36.5 : 1/2(18.0)

Ref: ST-EA-CP-D56008

Doxycycline-d3 Hyclate (Major)

Controlled Product

CAS: 24390-14-5

Applications Doxycycline-d3 Hyclate, is the labeled analogue of Doxycycline Hyclate (D561500), acting as an Antibacterial.
References Fabre, et al.: Chemotherapia, 11, 73 (1966), Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Polson, A.M., et al.: J. Periodontol., 68, 110 (1997),

Formula: (C₂₂H₂₁D₃N₂O₈)•2HCl•xH₂O•C₂H₆O

Color and Shape: Neat

Molecular weight: 2447.452364618

Ref: TR-D561503

Doxycycline hyclate

CAS: 24390-14-5

Antibiotic; anti-protozoal; anti-helmintic; protein synthesis inhibitor

Formula: C₂₂H₂₄N₂O₈•HCl•(C₂H₆O)₀•(H₂O)₀

Purity: Min. 95 Area-%

Color and Shape: Yellow Powder

Molecular weight: 512.94 g/mol

Ref: 3D-AA22608

Doxycycline hyclate - Bio-X ™

CAS: 24390-14-5

Doxycycline is a tetracycline antibiotic that is used to treat a range of bacterial infections. It is a broad-spectrum antibiotic. This drug inhibits bacterial protein synthesis by binding to its 30S prokaryotic ribosomal subunit. It also inhibits the production of essential proteins required for the bacterial to survive.

Formula: C₂₂H₂₄N₂O₈•HCl•(C₂H₆O)₀•(H₂O)₀

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 512.94 g/mol

Ref: 3D-BD166236

Doxycycline Hyclate (DXH), 800U/mg

CAS: 24390-14-5

Formula: C₂₂H₂₄N₂O₈·HClH₂OC₂H₆O

Color and Shape: Yellow, Hygroscopic crystalline powder

Molecular weight: 512.94

Ref: SR-65094

Doxycycline hydrochloride hemiethanolate hemihydrate, Antibiotic for Culture Media Use Only

CAS: 24390-14-5

Doxycycline is an antibiotic that inhibits bacterial growth by inhibiting protein synthesis, respiratory chain, DNA gyrase, DNA topoisomerase IV. Doxycycline inhibits papaverine by blocking the expression of both cytochrome P450 and epoxide hydrolase. Doxycycline is commonly found in studies for bacterial infections, drug therapy, histopathological studies, cell culture and chemometric analysis.

Formula: C₂₂H₂₄N₂O₈·HClH₂OC₂H₆O

Purity: Min. 97.0 Area-%

Molecular weight: 512.90 g/mol

Ref: 3D-Q-201047