CAS 64-73-3
:Demeclocycline hydrochloride
Description:
Demeclocycline hydrochloride is a broad-spectrum antibiotic belonging to the tetracycline class, primarily used to treat various bacterial infections. It is characterized by its ability to inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit, thereby preventing the growth and reproduction of the microorganisms. This compound is typically administered orally and is known for its effectiveness against a range of gram-positive and gram-negative bacteria. Demeclocycline hydrochloride is also utilized in the treatment of conditions such as acne and certain types of infections caused by resistant bacteria. In addition to its antibacterial properties, it has been used in the management of conditions like inappropriate antidiuretic hormone secretion (SIADH) due to its ability to induce nephrogenic diabetes insipidus. The substance is generally well-tolerated, but it can cause side effects such as gastrointestinal disturbances and photosensitivity. As with other tetracyclines, it is contraindicated in children and pregnant women due to potential effects on bone and teeth development.
Formula:C21H21ClN2O8·ClH
InChI:InChI=1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
InChI key:InChIKey=GVSJQNRGSCOSNJ-KBHRXELFSA-N
SMILES:O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C([C@H]3O)=C(Cl)C=CC4O)[H])[H].Cl
Synonyms:- 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
- 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride
- 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
- 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-
- 6,10,12,12A-Pentahydroxy-1,11-Dioxo-Ydro-Monohydrochloride
- 6-Demethyl-7-chlorotetracycline hydrochloride
- 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
- 7-Chloro-4-Dimethylamino-3,6,10,12,12A-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydro-Naphthacene-2-Carboxamide Hydrochloride
- 7-Chloro-6-Demethyltetracycline Hydrochloride
- Clortetrin
- Declomycin
- Declomycin hydrochloride
- Declomycinhydrochloride
- Demeclocycline
- Demethylchlorotetracycline hydrochloride
- Demethylchlorotetracyclinehydrochloride
- Demethylchlortetracyclinehydrochloride
- Demetraciclina
- Detravis
- Ledermycin hydrochloride
- See more synonyms
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Found 19 products.
Demeclocycline hydrochloride
CAS:Demeclocycline hydrochloride is used as an antibiotic related to tetracycline and produced by streptomyces aureofaciens, and used to maintain effective blood levels for longer periods of time, used as a fluorescent bone-labeling agent in bone histomorphometry. This Thermo Scientific Chemicals brandFormula:C21H21ClN2O8•HClMolecular weight:501.32DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRS
CAS:DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRSFormula:C21H22Cl2N2O8Color and Shape:Yellow. Powder.Molecular weight:501.314DEMECLOCYCLINE HYDROCHLORIDE CRS
CAS:DEMECLOCYCLINE HYDROCHLORIDE CRSFormula:C21H22Cl2N2O8Color and Shape:Yellow. Powder.Molecular weight:501.314Demeclocycline hydrochloride
CAS:Demeclocycline hydrochlorideFormula:C21H21ClN2O8HClPurity:90.2%Color and Shape:YellowMolecular weight:500.07532Demeclocycline Hydrochloride
CAS:Tetracyclines and their derivatives; salts thereofFormula:C21H21ClN2O8·HCIColor and Shape:Yellow Crystalline PowderMolecular weight:604.010947-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
CAS:Formula:C21H22Cl2N2O8Purity:90%Color and Shape:SolidMolecular weight:501.3140Ref: IN-DA0039UL
100gTo inquire500gTo inquire25mg46.00€100mg56.00€250mg67.00€1g109.00€5g197.00€10g239.00€25g615.00€Demeclocycline hydrochloride
CAS:Demeclocycline HCl (Declomycin), a tetracycline with 7-Cl & 6-CH₃, has prolonged blood levels due to slower excretion.Formula:C21H21ClN2O8·HClPurity:99.14% - 99.97%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:501.32(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride
CAS:(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide HydrochlorideFormula:C21H22Cl2N2O8Purity:90%Molecular weight:501.31Demeclocycline hydrochloride
CAS:Formula:C21H21ClN2O8·HClPurity:90.0 - 102.0 % (dried basis)Color and Shape:Yellow powderMolecular weight:501.32Demeclocycline hydrochloride
CAS:Demeclocycline hydrochlorideFormula:C21H21ClN2O8·HClPurity:≥95%Molecular weight:501.32Demeclocycline HCl
CAS:Formula:C21H21ClN2O8·HClColor and Shape:Yellow SolidMolecular weight:464.86 36.46Demeclocycline hydrochloride
CAS:Controlled ProductFormula:C21H21ClN2O8·ClHColor and Shape:NeatMolecular weight:501.31PharmaVetResiMix 5 Tetracyclines-v10 10 µg/mL in Methanol
CAS:Controlled ProductColor and Shape:MixtureDemeclocycline Hydrochloride
CAS:Controlled ProductFormula:C21H21ClN2O8·ClHColor and Shape:NeatMolecular weight:501.31Demeclocycline Hydrochloride
CAS:Applications An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.This compound is a contaminant of emerging concern (CECs).
References Jilka, R., et al.: J. Clin. Invest., 104, 439 (1999), Hauge, E; Bone, 28, 556 (2001), Dobnig, H., et al.: J. Clin. Endocrinol. Metab., 90, 3970 (2005),Formula:C21H21ClN2O8·ClHColor and Shape:NeatMolecular weight:501.31Demeclocycline hydrochloride
CAS:Demeclocycline hydrochloride is a tetracycline antibiotic that binds to the tetracycline receptor and inhibits bacterial protein synthesis. Demeclocycline hydrochloride has been shown to be effective against many types of bacteria, including those that are resistant to other antibiotics such as methicillin or vancomycin. Demeclocycline hydrochloride has been used in the treatment of skin cancer and also has anti-inflammatory properties. Demeclocycline hydrochloride is a hydrophobic molecule with a metal chelating ability that can be used for wastewater treatment.Formula:C21H21ClN2O8·ClHPurity:Min. 95%Color and Shape:White PowderMolecular weight:501.31 g/mol
