CAS 2468637-62-7
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PNU-142586 sodium
CAS:PNU-142586 sodium is the primary metabolite of Linezolid. It inhibits the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). By blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, PNU-142586 interferes with DNA replication and transcription, leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. It is useful for studying Linezolid-induced hematotoxicity and its molecular mechanisms.Formula:C16H20FN3NaO6Molecular weight:392.33
