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CAS 24916-90-3

:

Dexamethasone 9,11-epoxide

Description:
Dexamethasone 9,11-epoxide is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is derived from dexamethasone, a well-known glucocorticoid, and features an epoxide functional group at the 9 and 11 positions of the steroid structure, which can influence its biological activity and metabolism. The compound is typically used in various therapeutic applications, including the treatment of inflammatory conditions, autoimmune disorders, and certain types of cancer. Its mechanism of action involves the modulation of gene expression through interaction with glucocorticoid receptors, leading to reduced inflammation and immune response. Dexamethasone 9,11-epoxide is characterized by its stability under standard conditions, but like many corticosteroids, it may undergo metabolic conversion in the body. Safety and efficacy profiles are essential considerations in its use, as corticosteroids can have significant side effects, particularly with long-term administration. As with any pharmaceutical compound, proper handling and adherence to safety guidelines are crucial in both clinical and laboratory settings.
Formula:C22H28O5
InChI:InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)22(15)18(27-22)10-20(16,3)21(12,26)17(25)11-23/h6-7,9,12,15-16,18,23,26H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19+,20+,21+,22-/m1/s1
InChI key:InChIKey=GBDXNHBVYAMODG-QDBZYVRYSA-N
SMILES:C[C@@]12[C@@]34[C@]([C@]5([C@](C)(C[C@@]3(O4)[H])[C@](C(CO)=O)(O)[C@H](C)C5)[H])(CCC1=CC(=O)C=C2)[H]
Synonyms:
  • (9B,11B,16A)-9,11-Epoxy-17,21-Dihydroxy-16-Methyl-Pregna-1,4-Diene-3,20-Dione
  • (9β,11β,16α)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 16-Alpha Methyl Epoxide
  • 16-beta Methyl Epoxide
  • 16a-MethylEpoxide
  • 16α-Methyl epoxide(8-DM)
  • 17,21-Dihydroxy-16-Methyl-9,11-Epoxypregna-1,4-Diene-3,20-Dione
  • 8DM
  • 9β-Pregna-1,4-diene-3,20-dione, 9,11β-epoxy-17,21-dihydroxy-16α-methyl-
  • Dexamethasone 9,11-epoxide
  • Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16α)-
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Found 14 products.