CAS 25126-32-3

(27-tyr(so(3)H))cholecystokinin-fragment (26-33)-amide

Description:

The chemical substance known as "(27-tyr(so(3)H))cholecystokinin-fragment (26-33)-amide," with the CAS number 25126-32-3, is a peptide fragment derived from cholecystokinin (CCK), a hormone involved in digestion and satiety. This specific fragment consists of amino acids 26 to 33 of the CCK molecule, with a sulfated tyrosine at position 27, which is crucial for its biological activity. The presence of the sulfate group enhances the peptide's interaction with its receptors, influencing various physiological processes such as gallbladder contraction and enzyme secretion from the pancreas. The structure of this peptide includes a sequence of amino acids linked by peptide bonds, and it exhibits properties typical of peptides, such as solubility in water and stability under physiological conditions. Its biological significance is underscored by its role in the gastrointestinal system, making it a subject of interest in studies related to digestion, appetite regulation, and potential therapeutic applications in gastrointestinal disorders.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

InChI: InChI=1/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1

SMILES: CSCC[C@@H](C(=NCC(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCSC)C(=N[C@@H](CC(=O)O)C(=N[C@@H](Cc1ccccc1)C(=N)O)O)O)O)O)O)N=C([C@H](Cc1ccc(cc1)OS(=O)(=O)O)N=C([C@H](CC(=O)O)N)O)O

Synonyms:

• (tyr(so3H)27)-cholecystokinin fragment*26-33 amid
• Sincalide
• Cholecystokinin Octapeptide
• Tyr(SO3H]27)Cholecystokinin fragment 26-33 Amide
• alpha-aspartyl-O-sulfotyrosylmethionylglycyltryptophylmethionyl-alpha-aspartylphenylalaninamide
• L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
• Sincalide(CCK-8)
• Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
• Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-
• Cholecystokinin C-terminal octapeptide
• Cholecystokinin octapeptide (26-33 sulfated)
• Cholecystokinin-(26-33)-amide
• Cholecystokinin-8 (chicken)
• Cholecystokinin-8 (pig)
• Cholecystokinin-8 (Squalus acanthias)
• Cholecystokinin-8 (swine)
• Cholecystokinin-pancreozymin (swine intestine C-terminal octapeptide)
• Cholecystokinin-pancreozymin C-terminal octapeptide
• Human CCK-8
• L-Phenylalaninamide, L-α-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
• Sincalid
• Sincalida

Cholecystokinin, CCK Octapeptide (26-33)

CAS: 25126-32-3

For cellular and molecular biology applications

Color and Shape: White, Lyophilized Powder

Ref: 02-J66669

Cholecystokinin Octapeptide (sulfated)

CAS: 25126-32-3

CCK-8 exhibits various gastrointestinal effects as contraction of the gallbladder and stimulation of pancreatic secretion and gastrointestinal transit. In rats, CCK-8 facilitated the uptake of leptin from peripheral circulation to cerebrospinal fluid and its access to the hypothalamus.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purity: 98.42%

Color and Shape: White Powder

Molecular weight: 1143.29

Ref: 01-4033010

3-10-Caerulein, 5-L-methionine-

CAS: 25126-32-3

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 1143.2690

Ref: IN-DA002QKR

Sincalide

CAS: 25126-32-3

Sincalide

Purity: ≥98%

Molecular weight: 1143.27g/mol

Ref: 54-BUP02057

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

CAS: 25126-32-3

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Molecular weight: 1143.27

Ref: 7W-GL1683

Sincalide

CAS: 25126-32-3

Sincalide

Color and Shape: Powder

Molecular weight: 1,143.27g/mol

Ref: 54-BITH3042

Sincalide(CCK-8)

CAS: 25126-32-3

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 1143.27

Ref: BP-BPPG057

Sincalide

CAS: 25126-32-3

Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purity: 98.32%

Color and Shape: Solid

Molecular weight: 1143.27

Ref: TM-TP1197

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

CAS: 25126-32-3

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 is a versatile building block that can be used in research on complex compounds, fine chemicals, speciality chemicals and reagents. It is a high quality chemical that can be used as an intermediate or a scaffold. Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe NH2 is soluble in water and has a high degree of solubility in organic solvents. The compound is also stable under acidic conditions.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purity: Min. 98.0 Area-%

Molecular weight: 1,143.27 g/mol

Ref: 3D-W-107263

CCK-Octapeptide (26-33) (Sulfated Form)

CAS: 25126-32-3

CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purity: Min. 95%

Molecular weight: 1,143.3 g/mol

Ref: 3D-PCK-4100-V

Sincalide

CAS: 25126-32-3

Sincalide is a cholecystokinin (CCK) analog that has been used as a pharmacological agent. It is an agonist for CCK-A receptors and inhibits the activity of protein kinase C. Sincalide also has been shown to suppress tumor growth in experimental models. A polymerase chain reaction analysis of cck-8, a rat CCK receptor gene, showed a high degree of homology with human CCK-A receptor genes. The physiological effects of sincalide are complex and depend on the presence or absence of other hormones such as insulin, glucagon, somatostatin, and leptin.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,143.27 g/mol

Ref: 3D-FS41124