CAS 252916-29-3

Orantinib

Description:

Orantinib, with the CAS number 252916-29-3, is a small molecule that functions primarily as a tyrosine kinase inhibitor. It is designed to target specific pathways involved in tumor growth and angiogenesis, making it a candidate for cancer treatment. The compound exhibits a unique chemical structure that allows it to interact with various kinases, thereby inhibiting their activity and potentially slowing down the progression of certain cancers. Orantinib has shown promise in preclinical studies and clinical trials, particularly in the context of solid tumors. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are critical for determining its efficacy and safety profile. Additionally, like many targeted therapies, it may have a range of side effects, which necessitates careful monitoring during treatment. Overall, Orantinib represents a significant advancement in the development of targeted cancer therapies, reflecting ongoing research efforts in the field of oncology.

Formula: C₁₈H₁₈N₂O₃

InChI: InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)

InChI key: InChIKey=NHFDRBXTEDBWCZ-UHFFFAOYSA-N

SMILES: C(=C1C=2C(NC1=O)=CC=CC2)C3=C(C)C(CCC(O)=O)=C(C)N3

Synonyms:

• 1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
• 3-[2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic acid
• 3-[2,4-Dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propionic acid
• 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
• 3-[4-(2-Carboxyethyl)-3,5-dimethylpyrrol-2-methylidenyl]-2-indolinone
• 3-{2,4-dimethyl-5-[(E)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
• 5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
• NSC 702827
• Orantinib
• Su-6668
• Tsu-68

TSU-68 (Random Configuration)

CAS: 252916-29-3

Formula: C₁₈H₁₈N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 310.3471

Ref: IN-DA0037HX

Orantinib

CAS: 252916-29-3

Orantinib

Purity: ≥98%

Molecular weight: 310.35g/mol

Ref: 54-BUP10328

Orantinib

CAS: 252916-29-3

Ref: 7W-GW2996

Orantinib

CAS: 252916-29-3

Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.

Formula: C₁₈H₁₈N₂O₃

Purity: 98.92% - 99.52%

Color and Shape: Solid

Molecular weight: 310.35

Ref: TM-T6184

TSU-68

Controlled Product

CAS: 252916-29-3

Applications TSU-68 is a inhibitor that targets vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and fibroblast growth factor receptor 1. The inhibitory effects of TSU-68 towards these growth factors lead to substantial antitumor activity and showed potential in its development in therapeutic uses.
References Pandey, A.L., et al.: Med. Chem. Rsch., 2, 3958 (2012); Mahasenan, K.V., et al.: J. Chem. Info. Modeling., 52, 1345 (2012).

Formula: C₁₈H₁₈N₂O₃

Color and Shape: Neat

Molecular weight: 310.35

Ref: TR-T797550

TSU-68

CAS: 252916-29-3

Inhibitor of multiple tyrosine kinases

Formula: C₁₈H₁₈N₂o₃

Purity: Min. 95%

Ref: 3D-BT162331