CAS 252917-06-9

GSK 3 inhibitor XVI

Description:

GSK 3 inhibitor XVI, with the CAS number 252917-06-9, is a small molecule compound that selectively inhibits glycogen synthase kinase 3 (GSK-3), an enzyme involved in various cellular processes, including glycogen metabolism, cell signaling, and gene expression. This compound is particularly notable for its role in research related to neurodegenerative diseases, cancer, and diabetes, as GSK-3 is implicated in the pathology of these conditions. The inhibitor is characterized by its ability to modulate signaling pathways, particularly those involving Wnt and insulin, thereby influencing cellular proliferation and differentiation. GSK 3 inhibitor XVI is often utilized in biochemical assays and preclinical studies to explore therapeutic potentials and mechanisms of action. Its chemical structure typically includes specific functional groups that enhance its binding affinity and selectivity for GSK-3, making it a valuable tool in pharmacological research. As with many small molecule inhibitors, its efficacy and safety profile are subjects of ongoing investigation in various biological contexts.

Formula: C₂₂H₁₈Cl₂N₈

InChI: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)

InChI key: InChIKey=AQGNHMOJWBZFQQ-UHFFFAOYSA-N

SMILES: ClC1=C(C=2C(=CN=C(NCCNC3=CC=C(C#N)C=N3)N2)C=4NC(C)=CN4)C=CC(Cl)=C1

Synonyms:

• 3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-
• 3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-
• 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
• Chir 911
• Chir 99201
• Chir-99021
• Chir99021
• Cihr 99021
• Ct 99021
• GSK 3 inhibitor XVI
• Gsk 3Ixv

CHIR 99021 Hydrochloride Salt

Controlled Product

CAS: 252917-06-9

Applications CHIR 99021 Hydrochloride is an inhibitor of glycogen synthase kinase 3, which mimics Wnt signaling in preadipocytes. CHIR 99021 stabilizes free cytosolic β-​catenin and inhibits adipogenesis by blocking induction of CCAAT​/enhancer-​binding protein α and peroxisome proliferator-​activated receptor γ. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bennett, C., et al.: J. Bio. Chem., 277, 30998 (2002);

Formula: C₂₂H₁₈Cl₂N₈•xHCl

Color and Shape: Neat

Molecular weight: 465.343646

Ref: TR-C292157

CHIR-99021-d4

Controlled Product

CAS: 252917-06-9

Formula: C₂₂D₄H₁₄Cl₂N₈

Color and Shape: Neat

Molecular weight: 469.363

Ref: TR-C292147

CHIR 99021

CAS: 252917-06-9

Formula: C₂₂H₁₈Cl₂N₈

Molecular weight: 465.34

Ref: 4Z-C-427001

CHIR 99021 [Optimized for Cell Culture]

CAS: 252917-06-9

Formula: C₂₂H₁₈Cl₂N₈

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 465.34

Ref: 3B-C4010

CHIR99021

CAS: 252917-06-9

CHIR99021

Formula: C₂₂H₁₈Cl₂N₈

Purity: By hplc: >99% (Typical Value in Batch COA)

Color and Shape: off-white to beige solid

Molecular weight: 465.34g/mol

Ref: 54-BIFK0014

CHIR 99021

CAS: 252917-06-9

Formula: C₂₂H₁₈Cl₂N₈

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 465.34

Ref: 3B-C2943

CHIR 99021

CAS: 252917-06-9

Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.

Formula: C₂₂H₁₈Cl₂N₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 465.34 g/mol

Ref: 3D-FD43329

CHIR 99021-d4

CAS: 252917-06-9

Formula: C₂₂H₁₄D₄Cl₂N₈

Molecular weight: 469.37

Ref: 4Z-C-427002

CHIR-99021

CAS: 252917-06-9

View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.

Formula: C₂₂H₁₈Cl₂N₈

Purity: 97.94% - ≥95%

Color and Shape: Solid

Molecular weight: 465.34

Ref: TM-T2310

[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

CAS: 252917-06-9

Formula: C₂₂H₁₈Cl₂N₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 465.3379

Ref: IN-DA00385A