CAS 25526-94-7

3'-chloro-3'-deoxythymidine

Description:

3'-Chloro-3'-deoxythymidine, also known as 3'-CldT, is a nucleoside analog of thymidine, characterized by the presence of a chlorine atom at the 3' position of the sugar moiety. This modification imparts unique properties to the compound, making it of interest in medicinal chemistry, particularly in antiviral and anticancer research. The absence of the hydroxyl group at the 3' position, combined with the chlorine substitution, affects its ability to participate in nucleic acid synthesis, potentially inhibiting viral replication or tumor growth. 3'-CldT exhibits moderate solubility in water and is typically stable under physiological conditions, although it may undergo hydrolysis or other reactions under certain circumstances. Its mechanism of action often involves incorporation into DNA, leading to chain termination during replication. As a result, 3'-chloro-3'-deoxythymidine has been studied for its potential therapeutic applications, particularly in the treatment of viral infections and certain types of cancer, although further research is necessary to fully understand its efficacy and safety profiles.

Formula: C₁₀H₁₃ClN₂O₄

InChI: InChI=1/C10H13ClN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1

Zidovudine impurity standard

CAS: 25526-94-7, 30516-87-1, 50-89-5, 65-71-4

Zidovudine impurity standard

Color and Shape: Off White Solid

Ref: 47-895

Zidovudine Related Compound B (3'-chloro-3'-deoxythymidine)

CAS: 25526-94-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₀H₁₃ClN₂O₄

Color and Shape: White Off-White Powder

Molecular weight: 260.05638

Ref: 45-1724521

Zidovudine EP Impurity B

CAS: 25526-94-7

Formula: C₁₀H₁₃ClN₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 260.68

Ref: 4Z-Z-082

3'-Chloro-3'-deoxythymidine;

CAS: 25526-94-7

Nucleoside Derivatives - Halo-nucleosides, 2’,3’-Dideoxy nucleosides; Drugs and Inhibitors; Metabolite and related compound B of Zidovudine

Formula: C₁₀H₁₃ClN₂O₄

Color and Shape: Solid

Molecular weight: 260.67

Ref: TM-TNU1047

Zidovudine EP Impurity B

Controlled Product

CAS: 25526-94-7

Formula: C₁₀H₁₃ClN₂O₄

Color and Shape: Neat

Molecular weight: 260.67

Ref: 86-MM0173.02

Zidovudine EP Impurity B

CAS: 25526-94-7

Formula: C₁₀H₁₃ClN₂O₄

Molecular weight: 260.7

Ref: ST-EA-CP-Z6002

3'-Chloro-3'-Deoxythymidine

Controlled Product

CAS: 25526-94-7

Impurity Zidovudine EP Impurity B
Applications 3'-Chloro-3'-deoxythymidine (Zidovudine EP Impurity B) is an impurity of 3'-Azido-3'-deoxythymidine (A825000), a potent and selective inhibitor of HIV-1 replication and a potential antiviral agent.
References Navaneethan, G., et al.: J. Food. Drug Anal., 20, 446 (2012); Srivastav, N.C., et al.: Bioorg. Med. Chem., 18, 7542 (2010); Shakya, N., et al.: J. Med. Chem., 53, 4130 (2010); Fukushima, M., et al.: BIochem. Pharmacol., 59, 1227 (2000);

Formula: C₁₀H₁₃ClN₂O₄

Color and Shape: Beige

Molecular weight: 260.67

Ref: TR-C365575

3'-Deoxy-3'-chlorothymidine

CAS: 25526-94-7

3'-Deoxy-3'-chlorothymidine is an antiviral compound that is synthesized by the on-line coupling of 2,4-dichlorobenzoyl chloride with 3,4-dideoxycytidine. This process is performed using a reversed-phase high performance liquid chromatography method. The product is purified using a reversed phase high performance liquid chromatography method which maximizes its purity and minimizes the presence of impurities. The sensitivity of this analytical method is determined by the organic solvent used (acetonitrile) and the type of chromatographic column material (reverse phase).

Formula: C₁₀H₁₃ClN₂O₄

Purity: Min. 95%

Molecular weight: 260.67 g/mol

Ref: 3D-ID45199