CAS 30516-87-1

Azidothymidine

Description:

Azidothymidine, commonly known as AZT or zidovudine, is an antiretroviral medication primarily used in the treatment of HIV/AIDS. It is a nucleoside reverse transcriptase inhibitor (NRTI) that works by inhibiting the reverse transcriptase enzyme, thereby preventing the replication of the virus. AZT is characterized by its azido group, which distinguishes it from thymidine, a naturally occurring nucleoside. The compound is typically administered in its phosphate form, which is activated within the body to exert its antiviral effects. AZT is known for its ability to reduce the viral load in patients and improve immune function, although it may also cause side effects such as bone marrow suppression and gastrointestinal issues. Its chemical structure includes a pyrimidine base, and it is soluble in water, making it suitable for various formulations. AZT has played a significant role in HIV treatment regimens and remains a critical component in the management of the disease, particularly in combination therapies.

Formula: C₁₀H₁₃N₅O₄

InChI: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key: InChIKey=HBOMLICNUCNMMY-XLPZGREQSA-N

SMILES: O=C1N([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C=C(C)C(=O)N1

Synonyms:

• 1-(3-Azido-2,3-Dideoxy-Beta-D-Ribofuranosyl)Thymine
• 1-(3-azido-2,3-dideoxy-beta-D-threo-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(3-azido-2,3-dideoxypentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(4-Azido-5-Hydroxymethyl-Tetrahydro-Furan-2-Yl)-5-Methyl-1H-Pyrimidine-2,4-Dione
• 1-[(3xi)-3-azido-2,3-dideoxy-beta-D-glycero-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
• 3'-Azido-3'-Deoxythymidine
• 3'-Azido-3'-desoxythymidine
• 3'-Azido-3'-thymidine
• 3'-Azidothymidine
• 3'-Deoxy-3'-azidothymidine
• 3-Azido-3-deoxy-thymidine
• 3′-Azt
• AZT
• AZT (pharmaceutical)
• Azidothymidine
• Azitidin
• Bw-A 509U
• Compound S
• Nsc 602670
• Retrovir
• Retrovir IV
• Retrovis
• Thymidine, 3'-azido-3'-deoxy-
• Timazid
• Viro-Z
• ZDV
• ZVD
• Zido-H

3'-Azido-3'-deoxythymidine

CAS: 30516-87-1

Formula: C₁₀H₁₃N₅O₄

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 267.25

Ref: 3B-A2052

3'-Azido-3'-deoxythymidine, 98%

CAS: 30516-87-1

Anti-viral agent

Formula: C₁₀H₁₃N₅O₄

Purity: 98%

Color and Shape: White to yellow, Powder

Molecular weight: 267.25

Ref: 02-J65127

ZIDOVUDINE RS

CAS: 30516-87-1

ZIDOVUDINE RS

Formula: C₁₀H₁₃N₅O₄

Molecular weight: 267.2413

Ref: 41-ICRS1420

ZIDOVUDINE FOR SYSTEM SUITABILITY A CRS

CAS: 30516-87-1

ZIDOVUDINE FOR SYSTEM SUITABILITY A CRS

Ref: 41-Y0002266

ZIDOVUDINE CRS

CAS: 30516-87-1

ZIDOVUDINE CRS

Formula: C₁₀H₁₃N₅O₄

Color and Shape: White. Light Brown. Powder.

Molecular weight: 267.2413

Ref: 41-Z1900000

Zidovudine

CAS: 30516-87-1

Zidovudine

Formula: C₁₀H₁₃N₅O₄

Purity: 99.3%

Color and Shape: Off-White

Molecular weight: 267.09675

Ref: 47-803

Zidovudine impurity standard

CAS: 25526-94-7, 30516-87-1, 50-89-5, 65-71-4

Zidovudine impurity standard

Color and Shape: Off White Solid

Ref: 47-895

Zidovudine

CAS: 30516-87-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₀H₁₃N₅O₄

Color and Shape: White Light Yellow Crystalline Solid

Molecular weight: 267.24 g/mol

Ref: 45-1724500

Zidovudine

CAS: 30516-87-1

Zidovudine, a synthetic dideoxynucleoside, blocks DNA replication by inhibiting DNA polymerase after activation.

Formula: C₁₀H₁₃N₅O₄

Purity: 99.91% - 99.96%

Color and Shape: Solid

Molecular weight: 267.24

Ref: TM-T1416

Zidovudine

CAS: 30516-87-1

Zidovudine

Formula: C₁₀H₁₃N₅O₄

Purity: ≥98%

Molecular weight: 267.24

Ref: 54-BUP14929

3'-Azido-3'-deoxythymidine

CAS: 30516-87-1

Formula: C₁₀H₁₃N₅O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 267.2413

Ref: IN-DA0030EV

Zidovudine-13C-d3

CAS: 30516-87-1

Formula: C₉₁₃CH₁₀D₃N₅O₄

Color and Shape: Off-White Solid

Molecular weight: 271.26

Ref: 4Z-Z-089

Zidovudine

CAS: 30516-87-1

Formula: C₁₀H₁₃N₅O₄

Color and Shape: White To Off-White Solid

Molecular weight: 267.25

Ref: 4Z-Z-085

Zidovudine

CAS: 30516-87-1

Color and Shape: Neat

Ref: 86-MM0173.00

3'-Azido-3'-deoxythymidine

CAS: 30516-87-1

3'-Azido-3'-deoxythymidine

Formula: C₁₀H₁₃N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 267.24131

Ref: 54-OR8250T

3'-Azido-3'-deoxythymidine

CAS: 30516-87-1

3'-Azido-3'-deoxythymidine

Formula: C₁₀H₁₃N₅O₄

Purity: >98%

Color and Shape: Solid

Molecular weight: 267.24131

Ref: 54-BIMI8250

3''-Azido-3''-deoxythymidine

CAS: 30516-87-1

Formula: C₁₀H₁₃N₅O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 267.24

Ref: 7W-GN2140

Zidovudine RS

CAS: 30516-87-1

Color and Shape: White To Pale Yellow-White Solid Powder

Ref: 2K-106700002

3'-Azido-3'-deoxythymidine, Methyl-d3

Controlled Product

CAS: 30516-87-1

Applications A deuterated, potent and selective inhibitor of HIV-1 replication.
References Mitsuya, H., et al.: Nature, 325, 773 (1987), Brehm, J., et al.: Biochem., 47, 14020 (2008), Paredes, R., et al.: J. Virol., 83, 2038 (2009), Wan, J., et al.: J. Med. Chem., 52, 1144 (2009), Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009),

Formula: C₁₀H₁₀D₃N₅O₄

Color and Shape: Neat

Molecular weight: 270.26

Ref: TR-A825002

3'-Azido-3'-deoxythymidine

Controlled Product

CAS: 30516-87-1

Applications A potent and selective inhibitor of HIV-1 replication.
References Mitsuya, H., et al.: Nature, 325, 773 (1987), Brehm, J., et al.: Biochem., 47, 14020 (2008), Paredes, R., et al.: J. Virol., 83, 2038 (2009), Wan, J., et al.: J. Med. Chem., 52, 1144 (2009), Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009),

Formula: C₁₀H₁₃N₅O₄

Color and Shape: Neat

Molecular weight: 267.24

Ref: TR-A825000