CAS 2561529-98-2

Formula: C37H43ClFN7O5

InChI: InChI=1S/C37H43ClFN7O5/c1-25(39)36(49)46-19-18-45(22-27(46)11-14-40)35-29-12-17-44(32-10-3-7-26-6-2-9-30(38)34(26)32)23-31(29)41-37(42-35)51-24-28-8-4-15-43(28)16-5-20-50-21-13-33(47)48/h2-3,6-7,9-10,27-28H,1,4-5,8,11-13,15-24H2,(H,47,48)/t27-,28-/m0/s1

InChI key: MCHXOHQIEJIIKB-NSOVKSMOSA-N

SMILES: C=C(C(=O)N1CCN(C[C@@H]1CC#N)C2=NC(=NC3=C2CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)OC[C@@H]6CCCN6CCCOCCC(=O)O)F

MRTX849 ethoxypropanoic acid

CAS: 2561529-98-2

MRTX849 is a KRAS G12C ligand and PROTAC linker for creating potent LC-2, degrading KRAS G12C with DC50 of 0.25-0.76 μM.

Formula: C₃₇H₄₃ClFN₇O₅

Color and Shape: Solid

Molecular weight: 720.24

Ref: TM-T40190