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CAS 2566733-45-5

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  • HLB-0532259
    Targetmol
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    HLB-0532259

    CAS:
    <p>HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>
    Formula:C40H44N8O7
    Color and Shape:Solid
    Molecular weight:748.827

    Ref: TM-T204754