CAS 2566733-45-5

Formula: C40H44N8O7

InChI: InChI=1S/C40H44N8O7/c1-46(2)38(53)30-22-25-23-42-40(45-34(25)47(30)27-10-5-6-11-27)43-26-16-14-24(15-17-26)35(50)41-20-7-3-4-8-21-55-31-13-9-12-28-33(31)39(54)48(37(28)52)29-18-19-32(49)44-36(29)51/h9,12-17,22-23,27,29H,3-8,10-11,18-21H2,1-2H3,(H,41,50)(H,42,43,45)(H,44,49,51)

InChI key: AGMODSYVRUVEOY-UHFFFAOYSA-N

SMILES: CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)C(=O)NCCCCCCOC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O

HLB-0532259

CAS: 2566733-45-5

HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)

Formula: C₄₀H₄₄N₈O₇

Color and Shape: Solid

Molecular weight: 748.827

Ref: TM-T204754