CAS 25812-30-0

gemfibrozil

Description:

Gemfibrozil is a medication primarily used to lower lipid levels in patients with hyperlipidemia, particularly to reduce triglycerides and increase high-density lipoprotein (HDL) cholesterol. It belongs to the class of drugs known as fibrates and works by activating peroxisome proliferator-activated receptor alpha (PPARα), which enhances the oxidation of fatty acids and decreases the production of triglycerides in the liver. Chemically, gemfibrozil is characterized by its molecular formula, which includes carbon, hydrogen, and oxygen atoms, and it has a specific structural configuration that contributes to its pharmacological activity. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics involve extensive metabolism in the liver, primarily through glucuronidation, and it has a relatively long half-life, allowing for twice-daily dosing. Common side effects may include gastrointestinal disturbances, and it is contraindicated in patients with severe liver or kidney disease. As with any medication, monitoring lipid levels and potential drug interactions is essential during treatment.

Formula: C₁₅H₂₂O₃

InChI: InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChI key: InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N

SMILES: O(CCCC(C(O)=O)(C)C)C1=C(C)C=CC(C)=C1

Synonyms:

• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
• 5-[(2,5-Dimethylphenyl)oxy]-2,2-dimethylpentanoic acid
• Apo-Gemfibrozil
• Ausgem
• Bolutol
• Brn 1881200
• Brozil
• Ccris 318
• Cholespid
• Ci 719
• Clearol
• Decrelip
• Elmogan
• Fetinor
• Fibratol
• Fibrocit
• Gem-S
• Gemd
• Gemfibril
• Gemfibromax
• Gemfibrozil [USAN:INN:BAN]
• Gemfibrozilo
• Gemfibrozilo [INN-Spanish]
• Gemfibrozilum
• Gemfibrozilum [INN-Latin]
• Gemlipid
• Gemnpid
• Genlip
• Gevilon
• Gevilon Uno
• Gozid
• Hidil
• Hipolixan
• Hsdb 7735
• Innogen
• Ipolipid
• Jezil
• Lanaterom
• Lifibron
• Lipazil
• Lipigem
• Lipira
• Lipizyl
• Lipur
• Litarek
• Lopid
• Lopizid
• Low-Lip
• Micolip
• Normolip
• Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
• Pilder
• Polyxit
• Progemzal
• Reducel
• Regulip
• Renabrazin
• Sinelip
• Synbrozil
• Taborcil
• Tentroc
• Trialmin
• Trialmin 900
• Unii-Q8X02027X3
• Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-
• WL-Gemfibrozil
• Gemfibrozil
• 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANOICACID(GEMFIBROZIL)
• GEMFIBROZIL,USP
• 2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID
• 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoicaci
• 5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID
• Lipozid
• 2,2-dimethyl-5-(2,5-xylyloxy)-valericaci
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid
• Gemcitabine intermediates
• 5-(2,5-Dimethylphenoxy)-2,2-DimethylpentamoicAcid
• 2,2-Dimethyl-5-(2,5-Dimethylphenoxy)Valeric
• CI-7

Gemfibrozil

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 250.34

Ref: 3B-G0368

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Formula: C₁₅H₂₂O₃

Purity: 99.9%

Color and Shape: White Solid

Molecular weight: 250.15689

Ref: 47-363

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

CAS: 25812-30-0

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

Formula: C₁₅H₂₂O₃

Molecular weight: 250.3334

Ref: 41-Y0000514

GEMFIBROZIL CRS

CAS: 25812-30-0

GEMFIBROZIL CRS

Formula: C₁₅H₂₂O₃

Color and Shape: Added Modified

Molecular weight: 250.3334

Ref: 41-Y0000513

Gemfibrozil

CAS: 25812-30-0

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Formula: C₁₅H₂₂O₃

Color and Shape: Off-White White Powder

Molecular weight: 250.15689

Ref: 45-1288500

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.

Formula: C₁₅H₂₂O₃

Purity: 99.53% - 99.88%

Color and Shape: Crystals From Hexane Solid

Molecular weight: 250.3334

Ref: TM-T1415

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 250.3334

Ref: IN-DA0034YR

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Formula: C₁₅H₂₂O₃

Purity: ≥98%

Molecular weight: 250.33

Ref: 54-BUP14848

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Formula: C₁₅H₂₂O₃

Purity: >98%

Color and Shape: Solid

Molecular weight: 250.33

Ref: 54-OR1029081

Gemfibrozil

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White crystalline powder

Molecular weight: 250.33

Ref: 7W-GP1460

Gemfibrozil

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 250.34

Ref: 4Z-G-1211

Gemfibrozil (Standard)

CAS: 25812-30-0

Gemfibrozil (Standard) is the standard substance of Gemfibrozil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Formula: C₁₅H₂₂O₃

Molecular weight: 250.3334

Ref: TM-TMSM-1256

Gemfibrozil

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Color and Shape: Neat

Molecular weight: 250.33

Ref: 04-C13999000

Pharmaceuticals Mixture 327 200 µg/mL in Methanol

Controlled Product

CAS: 15687-27-1, 22204-53-1, 25812-30-0, 3380-34-5

Color and Shape: Mixture

Ref: 04-A50000327ME

Gemfibrozil

Controlled Product

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Color and Shape: Neat

Molecular weight: 250.33

Ref: 86-MM0641.00

Gemfibrozil 100 µg/mL in Acetonitrile

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Color and Shape: Single Solution

Molecular weight: 250.33

Ref: 04-A13999000AL-100

Gemfibrozil

Controlled Product

CAS: 25812-30-0

Applications A serum lipid regulating agent used as an antihyperlipoproteinemic.This compound is a contaminant of emerging concern (CECs).
References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)

Formula: C₁₅H₂₂O₃

Color and Shape: Neat

Molecular weight: 250.33

Ref: TR-G305750

Gemfibrozil

CAS: 25812-30-0

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

Formula: C₁₅H₂₂O₃

Purity: 98%

Molecular weight: 250.33

Ref: IN-DG32912

Gemfibrozil

CAS: 25812-30-0

Formula: C₁₅H₂₂O₃

Molecular weight: 250.34

Ref: ST-EA-CP-G25000

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil is a chemical inhibitor that inhibits the response element to the transcription factor PPAR-α. It has been shown to decrease cardiac effects such as increased heart rate, stroke volume, and cardiac output. Gemfibrozil has been used for wastewater treatment and has been found to be an analytical method for determining the concentration of other drugs in urine. The ecological effects of gemfibrozil are not well understood, but it is known that it can cause adverse effects on locomotor activity in animals. Gemfibrozil is a potent inducer of liver enzymes and may interact with other drugs by increasing their concentration time curve. This drug also has oral hypoglycemic properties, which lowers the blood glucose level by stimulating insulin production.

Formula: C₁₅H₂₂O₃

Purity: Min. 95%

Molecular weight: 250.33 g/mol

Ref: 3D-FD23652