Gemfibrozil

CAS: 25812-30-0

Ref. TM-T1415

Product Information

• Name: Gemfibrozil
• Synonyms: CI-719, Jezil, Decrelip, Lopid, 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid, 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure, 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure, 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid, 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid, 5-[(2,5-Dimethylphenyl)oxy]-2,2-dimethylpentanoic acid, Apo-Gemfibrozil, Ausgem, Bolutol, Brn 1881200, Brozil, Ccris 318, Cholespid, Ci 719, Clearol, Decrelip, Elmogan, Fetinor, Fibratol, Fibrocit, Gem-S, Gemd, Gemfibril, Gemfibromax, Gemfibrozil [USAN:INN:BAN], Gemfibrozilo, Gemfibrozilo [INN-Spanish], Gemfibrozilum, Gemfibrozilum [INN-Latin], Gemlipid, Gemnpid, Genlip, Gevilon, Gevilon Uno, Gozid, Hidil, Hipolixan, Hsdb 7735, Innogen, Ipolipid, Jezil, Lanaterom, Lifibron, Lipazil, Lipigem, Lipira, Lipizyl, Lipur, Litarek, Lopid, Lopizid, Low-Lip, Micolip, Normolip, Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-, Pilder, Polyxit, Progemzal, Reducel, Regulip, Renabrazin, Sinelip, Synbrozil, Taborcil, Tentroc, Trialmin, Trialmin 900, Unii-Q8X02027X3, Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-, WL-Gemfibrozil
• CAS: 25812-30-0

Description

Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

• Brand: Targetmol

Chemical properties

• Molecular weight: 250.33
• Formula: C₁₅H₂₂O₃
• Purity: 99.9%
• Color/Form: Crystals From Hexane Solid