CAS 260779-88-2: Cisapride monohydrate
Description:Cisapride monohydrate is a pharmaceutical compound primarily used as a prokinetic agent to enhance gastrointestinal motility. It belongs to the class of substituted benzamides and acts as a selective serotonin 5-HT4 receptor agonist, promoting the release of acetylcholine in the gastrointestinal tract. This action facilitates gastric emptying and improves esophageal motility, making it beneficial for conditions like gastroesophageal reflux disease (GERD) and functional dyspepsia. The monohydrate form indicates that the compound contains one molecule of water per molecule of cisapride, which can influence its solubility and stability. Cisapride has a relatively low solubility in water, which can affect its bioavailability. However, it is important to note that cisapride has been associated with serious cardiac side effects, leading to its withdrawal from the market in many countries. As a result, its use is now limited and closely monitored in clinical settings. Overall, cisapride monohydrate is characterized by its pharmacological properties, structural features, and safety profile, which are critical for its application in medical treatments.
Formula:C23H29ClFN3O4·H2O
InChI:InChI=1/C23H29ClFN3O4.H2O/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16;/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29);1H2/t20-,22+;/s2
InChI key:InChIKey=QBYYXIDJOFZORM-IQBRHYPJNA-N
SMILES:O=C(NC1CCN(CCCOC2=CC=C(F)C=C2)CC1OC)C=3C=C(Cl)C(N)=CC3OC.O
- Synonyms:
- Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, monohydrate, rel-
- Cisapride monohydrate
- Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, hydrate (1:1), rel-
![Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-me…](https://static.cymitquimica.com/products/IN/thumb/DA002RLL.jpg)
