CAS 262352-17-0

Torcetrapib

Description:

Torcetrapib is a synthetic compound that belongs to the class of cholesterol ester transfer protein (CETP) inhibitors. It was primarily developed for the treatment of dyslipidemia, aiming to raise high-density lipoprotein (HDL) cholesterol levels while lowering low-density lipoprotein (LDL) cholesterol levels. The molecular structure of Torcetrapib includes a complex arrangement of functional groups that contribute to its pharmacological activity. It is characterized by its ability to modulate lipid metabolism, which can potentially lead to improved cardiovascular outcomes. However, clinical trials revealed that despite its efficacy in raising HDL levels, Torcetrapib was associated with adverse cardiovascular events, leading to its discontinuation in further development. The compound has a relatively high molecular weight and exhibits specific solubility properties, influencing its bioavailability and pharmacokinetics. Overall, while Torcetrapib demonstrated potential in lipid management, its safety profile ultimately limited its therapeutic application.

Formula: C₂₆H₂₅F₉N₂O₄

InChI: InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1

InChI key: InChIKey=CMSGWTNRGKRWGS-NQIIRXRSSA-N

SMILES: N(CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(C(OC)=O)[C@@H]2C=3C(N(C(OCC)=O)[C@H](CC)C2)=CC=C(C(F)(F)F)C3

Synonyms:

• (2R,4S)-4-[(3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
• (2R,4S)-4-[[3,5-Bis(trifluoromethyl)benzyl]methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
• 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-
• Cp 529414
• ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
• Torcetrapib

1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-

CAS: 262352-17-0

Formula: C₂₆H₂₅F₉N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 600.4733

Ref: IN-DA002SDU

Torcetrapib

CAS: 262352-17-0

Formula: C₂₆H₂₅F₉N₂O₄

Molecular weight: 600.47

Ref: 7W-GL0371

Torcetrapib

CAS: 262352-17-0

Torcetrapib

Purity: ≥98%

Molecular weight: 600.47g/mol

Ref: 54-BUP11506

Torcetrapib

CAS: 262352-17-0

Formula: C₂₆H₂₅F₉N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 600.49

Ref: 4Z-T-119001

Torcetrapib

CAS: 262352-17-0

Torcetrapib (CP-529414), a CETP inhibitor, curbs cholesteryl ester movement from HDL to LDL/VLDL; failed Phase III trials due to mortality increase.

Formula: C₂₆H₂₅F₉N₂O₄

Purity: 98% - 99.59%

Color and Shape: Lipid

Molecular weight: 600.47

Ref: TM-T2499

Torcetrapib

Controlled Product

CAS: 262352-17-0

Applications Cholesteryl ester transfer protein (CETP) inhibitor. Antilipemic; antiatherosclerotic.
References Burnett, J.R., et al.: Curr. Opin. Invest. Drugs, 6, 944 (2005), Clark, R.W., et al.: J. Lipid Res., 47, 537 (2006),

Formula: C₂₆H₂₅F₉N₂O₄

Color and Shape: Neat

Molecular weight: 600.47

Ref: TR-T546500