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CAS 262352-17-0

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Torcetrapib

Description:
Torcetrapib is a synthetic compound that belongs to the class of cholesterol ester transfer protein (CETP) inhibitors. It was primarily developed for the treatment of dyslipidemia, aiming to raise high-density lipoprotein (HDL) cholesterol levels while lowering low-density lipoprotein (LDL) cholesterol levels. The molecular structure of Torcetrapib includes a complex arrangement of functional groups that contribute to its pharmacological activity. It is characterized by its ability to modulate lipid metabolism, which can potentially lead to improved cardiovascular outcomes. However, clinical trials revealed that despite its efficacy in raising HDL levels, Torcetrapib was associated with adverse cardiovascular events, leading to its discontinuation in further development. The compound has a relatively high molecular weight and exhibits specific solubility properties, influencing its bioavailability and pharmacokinetics. Overall, while Torcetrapib demonstrated potential in lipid management, its safety profile ultimately limited its therapeutic application.
Formula:C26H25F9N2O4
InChI:InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
InChI key:InChIKey=CMSGWTNRGKRWGS-NQIIRXRSSA-N
SMILES:N(CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(C(OC)=O)[C@@H]2C=3C(N(C(OCC)=O)[C@H](CC)C2)=CC=C(C(F)(F)F)C3
Synonyms:
  • (2R,4S)-4-[(3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
  • (2R,4S)-4-[[3,5-Bis(trifluoromethyl)benzyl]methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
  • 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-
  • Cp 529414
  • ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • Torcetrapib
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