CAS 2645-32-1

PR-619

Description:

PR-619, with the CAS number 2645-32-1, is a chemical compound known primarily as a proteasome inhibitor. It is characterized by its ability to interfere with the proteasome's function, which is crucial for protein degradation and regulation within cells. This inhibition can lead to the accumulation of proteins that regulate various cellular processes, including cell cycle progression and apoptosis. PR-619 has been studied for its potential therapeutic applications, particularly in cancer treatment, as it may enhance the efficacy of certain chemotherapeutic agents by disrupting the balance of protein turnover in cancer cells. Additionally, PR-619 is often utilized in research settings to investigate the role of the ubiquitin-proteasome pathway in various biological processes. Its solubility and stability in different solvents can vary, making it important to consider these factors when designing experiments. Overall, PR-619 serves as a valuable tool in both therapeutic and research contexts, contributing to our understanding of cellular mechanisms and potential treatment strategies.

Formula: C₇H₅N₅S₂

Synonyms:

• 2,6-Diaminopyridine-3,5-bis(thiocyanate)
• PR-619;PR619
• PR-619
• 2,6-Diamino-3,5-dithiocyanopyridine PR 619
• 2,6-Diamino-3,5-dithiocyanato-pyridin, 98%
• PR 619 2,6-Diamino-3,5-dithiocyanopyridine
• 6-Diamino-3
• 2,6-DiaMino-3,5-dithiocyanopyridine
• 3,5-Bis-thiocyanato-pyridine-2,6-diamine
• 5-dithiocyanopyridine
• Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester
• 2;6-DIAMINO-3;5-DITHIOCYANOPYRIDINE;PR 619;PR619
• CS-1128
• PR-619, >=98%
• 3,5-dithiocyanatopyridine-2,6-diaMine

Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester

CAS: 2645-32-1

Formula: C₇H₅N₅S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 223.2781

Ref: IN-DA002TAH

PR-619

CAS: 2645-32-1

PR-619

Purity: ≥95%

Molecular weight: 223.28g/mol

Ref: 54-BUP10178

PR-619

CAS: 2645-32-1

PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.

Formula: C₇H₅N₅S₂

Purity: 97.25% - >99.99%

Color and Shape: Solid

Molecular weight: 223.28

Ref: TM-T1862

3,5-Dithiocyanatopyridine-2,6-diamine

CAS: 2645-32-1

Formula: C₇H₅N₅S₂

Purity: 98%

Color and Shape: Liquid, No data available.

Molecular weight: 223.27

Ref: 10-F462084

PR 619

Controlled Product

CAS: 2645-32-1

Applications PR 619 is a broad-range DUB inhibitor. A selective and general inhibitior of cellular DUB activity without direct impairment of proteasomal proteolysis. Used in the preparation of thiazolopyridines and bisthiazolopyridines.
References Altun, M. et al.: Chem. Biol., 18, 1401 (2011); Baker, J. & Hill, S.: J. Chem. Soc., 3464 (1962)

Formula: C₇H₅N₅S₂

Color and Shape: Neat

Molecular weight: 223.278

Ref: TR-P699010

PR-619

CAS: 2645-32-1

PR-619 is a small molecule that inhibits the ubiquitin ligases Nedd4 and HECTD1, leading to the activation of autophagy. PR-619 also inhibits protease activity in cancer cells. It has been shown to specifically target microbial infections such as tuberculosis and malaria. PR-619 has shown promise for treating urothelial carcinoma, heparin-induced thrombocytopenia, mesenchymal markers, and body formation.

Formula: C₇H₅N₅S₂

Purity: Min. 95%

Molecular weight: 223.28 g/mol

Ref: 3D-CAA64532