Ubiquitination
Ubiquitination inhibitors are compounds that interfere with the process of ubiquitination, where proteins are tagged with ubiquitin molecules for degradation by the proteasome. These inhibitors are critical for studying protein turnover, signal transduction, and the regulation of various cellular processes. Ubiquitination plays a key role in many diseases, including cancer, neurodegenerative disorders, and immune system dysfunction. By modulating ubiquitination, these inhibitors can provide insights into the mechanisms of disease and open up new avenues for therapeutic intervention. At CymitQuimica, we offer a wide selection of high-quality ubiquitination inhibitors to support your research in cell biology, proteomics, and drug discovery.
Subcategories of "Ubiquitination"
Found 71 products for "Ubiquitination".
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ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Formula:C21H23BrN6O5SPurity:99.32% - 99.82%Color and Shape:SolidMolecular weight:551.414NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Formula:C6H7N3O3Purity:97.72%Color and Shape:SolidMolecular weight:169.1381WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Formula:C18H21Cl2N9S2Purity:98.46%Color and Shape:SolidMolecular weight:498.456Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Formula:C33H31F4N7OColor and Shape:SolidMolecular weight:617.25262Antitumor agent-153
Antitumor agent-153 (compound 11b) is an inhibitor of H2A histone ubiquitination, optimized from PRT4165. It can reduce the viability of human osteosarcoma U2OS cells and decrease monoubiquitination of histone H2A, demonstrating anticancer activity.Formula:C16H8N2O6Color and Shape:SolidMolecular weight:324.03824Post-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Color and Shape:Odour SolidCbl-b-IN-19
Cbl-b-IN-19 (Compound 49) is an inhibitor of the E3 ligase Cbl-b, effectively suppressing its phosphorylation with an IC50 of less than 100 nM.Formula:C34H31F3N8OColor and Shape:SolidMolecular weight:624.25729dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.Formula:C14H11ClN4OSPurity:98.48% - 99.49%Color and Shape:SolidMolecular weight:318.781MRC37
MRC37 is a potent and selective small molecule ligand for TRIM21, binding to the PRYSPRY domain of TRIM21. It inhibits the innate antiviral function of TRIM21 by preventing antibody neutralization of adenovirus 5 (Adv5). Additionally, MRC37 can inhibit the Trim-Away technique, a targeted protein degradation method that recruits TRIM21 to specific proteins via electroporated antibodies.Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Color and Shape:Odour SolidCbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Formula:C27H27N5O3Color and Shape:SolidMolecular weight:469.21139SAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Formula:C27H30ClN5O5S2Color and Shape:SolidMolecular weight:603.13769Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Color and Shape:Odour SolidMSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formula:C29H29F3N2Color and Shape:SolidMolecular weight:462.5492LS-102
CAS:LS-102: E3 ligase inhibitor, IC50 35 μM, potential RA therapy.Formula:C24H36N8OPurity:98.92%Color and Shape:SolidMolecular weight:452.5956BRD5529
CAS:BRD5529 selective CARD9–TRIM62 interaction inhibitor for ubiquitination pathway regulation, innate immunity, inflammatory signaling and CARD9 immune response research.Formula:C25H31N5O4Color and Shape:SolidMolecular weight:465.5447NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formula:C27H28N4O3S2Purity:99.05% - 99.85%Color and Shape:SolidMolecular weight:520.666CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Formula:C23H27N3O4Purity:98.02% - 99.48%Color and Shape:White SolidMolecular weight:409.4782Skp2 Inhibitor C1
CAS:Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Formula:C18H13BrN2O4S2Purity:97.36%Color and Shape:SolidMolecular weight:465.341MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurity:99.39%Color and Shape:SolidMolecular weight:293.298
