CAS 2648279-76-7

Formula: C26H26N6O2

InChI: InChI=1S/C26H26N6O2/c1-26(2,3)23-13-25(34-30-23)29-24(33)11-17-5-8-20(9-6-17)32-16-27-21-12-18(7-10-22(21)32)19-14-28-31(4)15-19/h5-10,12-16H,11H2,1-4H3,(H,29,33)

InChI key: VIQAAPJVSOWKQK-UHFFFAOYSA-N

SMILES: CC(C)(C)C1=NOC(=C1)NC(=O)CC2=CC=C(C=C2)N3C=NC4=C3C=CC(=C4)C5=CN(N=C5)C

Multi-kinase inhibitor 3

CAS: 2648279-76-7

Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC₅₀ values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.

Formula: C₂₆H₂₆N₆O₂

Color and Shape: Solid

Molecular weight: 454.52

Ref: TM-T200518