CAS: 265121-04-8 - Fosaprepitant dimeglumine

Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

InChI: InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19+,20-;4-,5+,6+,7+/m10/s1

InChI key: InChIKey=UGJUJYSRBQWCEK-GGXTVIBHSA-N

SMILES: O=C1NC(=NN1P(=O)(O)O)CN2CCOC(OC(C=3C=C(C=C(C3)C(F)(F)F)C(F)(F)F)C)C2C4=CC=C(F)C=C4.OCC(O)C(O)C(O)C(O)CNC

Synonyms:

• 1-Deoxy-1-(Methylamino)-D-Glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-4-Morpholinyl]Methyl]-2,5-Dihydro-5-Oxo-1H-1,2,4-Triazol-1-Yl]Phosphonate
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1)
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
• D-Glucitol, 1-deoxy-1-(methylamino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1) (salt)
• Fosaprepitant di(N-methylglucamine)
• Fosaprepitant dimeglumine [USAN]
• Ivemend
• Mk-0517
• Phosphonic acid, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
• Phosphonic acid, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-, compd. with 1-deoxy-1-(methylamino)-<span class="text-smallcaps">D</span>-glucitol (1:2)
• Unii-D35Fm8T64X
• Fosaprepitant dimeglumine
• Fosapitant Dimeglumine
• D-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1)

Fosaprepitant dimeglumine

CAS: 265121-04-8

• Formula: C₃₇H₅₆F₇N₆O₁₆P
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 1004.8337

Fosaprepitant Dimeglumine

CAS: 265121-04-8

• Formula: C₂₃H₂₂F₇N₄O₆PC₇H₁₇NO₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 614.41 2*195.22

Fosaprepitant-d4 Dimeglumine

CAS: 265121-04-8

• Formula: C₂₃H₁₈D₄F₇N₄O₆PC₇H₁₇NO₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 618.44 2*195.22

Fosaprepitant Dimeglumine

CAS: 265121-04-8

• Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅
• Purity: >95.0%(HPLC)(qNMR)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 1,004.84

Fosaprepitant Impurity 10

CAS: 265121-04-8

• Formula: C₂₃H₂₂F₇N₄O₇P
• Color and Shape: White To Off-White Solid
• Molecular weight: 630.42

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine (MK-0517) is a soluble prodrug of aprepitant, which prevents nausea by blocking NK1 …

• Formula: C₃₇H₅₆F₇N₆O₁₆P
• Purity: 97.39% - 98.75%
• Color and Shape: Solid
• Molecular weight: 1004.83

bis((2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol); (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid

CAS: 265121-04-8

• Purity: 98.05%
• Molecular weight: 1004.844

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Applications Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a …

• Formula: C₂₃H₂₂F₇N₄O₆PC₇H₁₇NO₅
• Color and Shape: Off White
• Molecular weight: 1004.83

Fosaprepitant-d4 Dimeglumine

CAS: 265121-04-8

Applications Fosaprepitant-d4 Dimeglumine is a labeled analogue of Fosaprepitant Dimeglumine (F727305), a selective neurokinin-1 (NK-1) …

• Formula: C₃₇H₅₂D₄F₇N₆O₁₆P
• Color and Shape: Neat
• Molecular weight: 1008.86

1-Deoxy-1-(methylamino)-D-glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]m ethyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate

CAS: 265121-04-8

Fosaprepitant is a drug that belongs to the class of drugs used for chemotherapy. It …

• Formula: C₂₃H₂₂F₇N₄O₆P•(C₇H₁₇NO₅)₂
• Purity: Min. 95%
• Color and Shape: White To Off-White Solid
• Molecular weight: 1,004.83 g/mol

Fosaprepitant-13C,15N3 Dimeglumine

CAS: 265121-04-8

• Formula: C₃₆CH₅₆F₇N₃N₃O₁₆P
• Color and Shape: Neat
• Molecular weight: 1008.82