CAS 265651-18-1

N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate

Description:

N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate, commonly referred to as HATU, is a coupling reagent widely used in peptide synthesis and other organic reactions. It is characterized by its ability to activate carboxylic acids for amide bond formation, facilitating the coupling of amino acids in peptide synthesis. The compound is typically a white to off-white solid and is soluble in polar organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). HATU is known for its efficiency and mild reaction conditions, which minimize side reactions and enhance yield. It is also favored for its stability under standard laboratory conditions, although it should be handled with care due to its reactivity and potential toxicity. The presence of the succinimidyl group allows for selective reactions with amines, making it a valuable tool in the synthesis of complex organic molecules. Proper storage in a cool, dry place away from moisture is recommended to maintain its integrity and effectiveness.

Formula: C₉H₁₆F₆N₃O₃P

InChI: InChI=1/C9H16N3O3.F6P/c1-10(2)9(11(3)4)15-12-7(13)5-6-8(12)14;1-7(2,3,4,5)6/h5-6H2,1-4H3;/q+1;-1

InChI key: STWZCCVNXFLDDD-UHFFFAOYSA-N

SMILES: CN(C)C(=[N+](C)C)ON1C(=O)CCC1=O.F[P-](F)(F)(F)(F)F

Synonyms:

• Hstu
• O-(N-Succinimidyl)-1,1,3,3-tetramethyluronium hexafluorophosphate
• N-{(dimethylamino)[(2,5-dioxopyrrolidin-1-yl)oxy]methylidene}-N-methylmethanaminium hexafluorophosphate

N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium Hexafluorophosphate

CAS: 265651-18-1

Formula: C₉H₁₆F₆N₃O₃P

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 359.21

Ref: 3B-T2929

O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 98+%

CAS: 265651-18-1

Coupling reagent for peptide synthesis and the formation of other amides. Reactant for synthesis of liposomal contrast agents for magnetic resonance imaging, synthesis of protein labeling molecules, synthesis of thiol-reactive Cy5 derivatives.This Thermo Scientific Chemicals brand product was origin

Formula: C₉H₁₆F₆N₃O₃P

Purity: 98+%

Molecular weight: 359.21

Ref: 02-H54035

O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate

CAS: 265651-18-1

O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate

Formula: C₉H₁₆N₃O₃·PF₆

Purity: >98%

Color and Shape: Solid

Molecular weight: 359.20582

Ref: 54-PC8351

N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate

CAS: 265651-18-1

Formula: C₉H₁₆F₆N₃O₃P

Purity: 96%

Color and Shape: Solid

Molecular weight: 359.2058

Ref: IN-DA002TPN

N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium Hexafluorophosphate

CAS: 265651-18-1

N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium Hexafluorophosphate

Formula: C₉H₁₆F₆N₃O₃P

Purity: 98%

Molecular weight: 359.21

Ref: IN-DG19825

HSTU

CAS: 265651-18-1

HSTU is an uronium salt used as an amide and ester coupling reagent, and to form NHS esters from carboxylic acids. HSTU is used in the last step of the synthesis of the protein labelling agent N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB), which can be efficiently made using batch microfluidic technology. HSTU finds application in the synthesis of pH-sensitive dyes to be used as contrast agents for cellular uptake studies. HSTU is also used in the synthesis of monodendronised perylene bisimides and their bioconjugates to be used as fluorescent labels. HSTU is utilised in the synthesis of biodegradable core multi-shell nanocarriers used as drug delivery systems.

Formula: C₉H₁₆F₆N₃O₃P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 359.21 g/mol

Ref: 3D-FH15578

HSTU

CAS: 265651-18-1

Formula: C₉H₁₆F₆N₃O₃P

Purity: 96%

Color and Shape: Solid

Molecular weight: 359.083

Ref: 10-F045171