CAS 26718-25-2

Halofenate

Description:

Halofenate is a chemical compound characterized by its use as an anti-inflammatory and analgesic agent. It belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) and is often utilized in the treatment of various inflammatory conditions. The compound exhibits properties that inhibit the synthesis of prostaglandins, which are mediators of inflammation and pain. Halofenate is typically administered in a pharmaceutical formulation, and its efficacy is attributed to its ability to modulate the body's inflammatory response. The compound is known for its relatively low toxicity profile when used as directed, although potential side effects may include gastrointestinal disturbances and allergic reactions in sensitive individuals. As with many NSAIDs, caution is advised in patients with pre-existing conditions such as peptic ulcer disease or renal impairment. Overall, Halofenate represents a valuable therapeutic option in the management of pain and inflammation, contributing to the broader category of NSAIDs used in clinical practice.

Formula: C₁₉H₁₇ClF₃NO₄

InChI: InChI=1/C19H17ClF3NO4/c1-12(25)24-9-10-27-18(26)17(13-5-7-15(20)8-6-13)28-16-4-2-3-14(11-16)19(21,22)23/h2-8,11,17H,9-10H2,1H3,(H,24,25)

InChI key: BJBCSGQLZQGGIQ-UHFFFAOYSA-N

SMILES: CC(=NCCOC(=O)C(c1ccc(cc1)Cl)Oc1cccc(c1)C(F)(F)F)O

Synonyms:

• Halofenate [USAN:INN:BAN]
• (p-Chlorophenyl)((alpha,alpha,alpha-trifluoro-m-tolyl)oxy)acetic acid ester with N-(2-hydroxyethyl)acetamide
• 2-Acetamidoethyl 2-(4-chlorphenyl)-2-(3-trifluormethylphenoxy)acetat
• Benzeneacetic acid, 4-chloro-alpha-(3-(trifluoromethyl)phenoxy)-, 2-(acetylamino)ethyl ester
• Halofenato
• Halofenato [INN-Spanish]
• Halofenatum
• Halofenatum [INN-Latin]
• Mk 185
• 2-(Acetylamino)Ethyl (4-Chlorophenyl)[3-(Trifluoromethyl)Phenoxy]Acetate
• Halofenate

Halofenate

Controlled Product

CAS: 26718-25-2

Formula: C₁₉H₁₇ClF₃NO₄

Color and Shape: Neat

Molecular weight: 415.791

Ref: TR-H102455

Halofenate

CAS: 26718-25-2

Halofenate is an inhibitor for hypertriglyceridemia, effectively lowering serum triglyceride levels while having minimal impact on serum cholesterol. Additionally, it reduces serum uric acid and promotes uric acid excretion independent of glomerular filtration rate. Halofenate is associated with a significant increase in plasma thyroxine (T4), along with reductions in protein-bound iodine and T4. It can displace T4 from thyroid-binding proteins, which may influence thyroid function in the body.

Formula: C₁₉H₁₇ClF₃NO₄

Color and Shape: Solid

Molecular weight: 415.79

Ref: TM-T210319