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CAS 26807-65-8

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Indapamide

Description:
Indapamide is a thiazide-like diuretic primarily used in the treatment of hypertension and edema associated with heart failure. It is characterized by its ability to inhibit sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased urine output and decreased blood pressure. Indapamide is known for its relatively long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound is typically administered in oral form and is often favored for its additional vasodilatory effects, which can contribute to its antihypertensive properties. Indapamide is also distinguished by its low potential for electrolyte imbalance compared to traditional thiazide diuretics, making it a preferred choice in certain patient populations. Its chemical structure includes a sulfonamide group, which is integral to its mechanism of action. As with any medication, potential side effects may include dizziness, electrolyte disturbances, and gastrointestinal issues, necessitating monitoring during treatment.
Formula:C16H16ClN3O3S
InChI:InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
InChI key:InChIKey=NDDAHWYSQHTHNT-UHFFFAOYSA-N
SMILES:N(C(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1)N2C=3C(CC2C)=CC=CC3
Synonyms:
  • 1-(4-Chloro-3-Sulfamoylbenzamido)-2-Methylindoline
  • 3-(Aminosulfonyl)-4-Chloro-N-(2,3-Dihydro-2-Methyl-1H-Indol-1-Yl)-Benzamid
  • 3-(Aminosulfonyl)-4-Chloro-N-(2,3-Dihydro-2-Methyl-1H-Indol-1-Yl)Benzamide
  • 4-Chloro-N-(2-Methyl-1-Indolinyl)-3-Sulfamoyl-Benzamid
  • 4-Chloro-N-(2-Methyl-1-Indolinyl)-3-Sulfamoylbenzamide
  • 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
  • Arifon
  • Bajaten
  • Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-
  • Benzamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-
  • See more synonyms
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