CAS 26833-87-4: Homoharringtonine

Description: Homoharringtonine, with the CAS number 26833-87-4, is a natural alkaloid derived from the plant species Cephalotaxus harringtonia. It is primarily known for its role as an antineoplastic agent, particularly in the treatment of certain types of leukemia, such as acute myeloid leukemia (AML). The compound functions by inhibiting protein synthesis, which ultimately leads to the suppression of cancer cell proliferation. Homoharringtonine exhibits a unique mechanism of action by targeting the eukaryotic translation initiation process, making it distinct from other chemotherapeutic agents. It is typically administered intravenously and has been studied for its efficacy in combination with other chemotherapy drugs. The substance is characterized by its complex molecular structure, which includes multiple chiral centers, contributing to its biological activity. While it shows promise in clinical applications, its use may be associated with side effects, including myelosuppression and gastrointestinal disturbances. Ongoing research continues to explore its potential and optimize its therapeutic use in oncology.

Formula: C₂₉H₃₉NO₉

InChI: InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1

InChI key: InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N

SMILES: O=C(OC)CC(O)(C(=O)OC1C(OC)=CC23N(CCC4=CC=5OCOC5C=C4C12)CCC3)CCCC(O)(C)C

Synonyms:

• (4alpha)-O~3~-[2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Brn 5687925
• Ceflatonin
• Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI)
• Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI)
• Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cgx-635
• Myelostat
• Nsc 141633
• Omacetaxine mepesuccinate
• Omacetaxine mepesuccinate [USAN]
• Omapro
• O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• Synribo
• Unii-6Fg8041S5B
• Homoharringtonine

Homoharringtonine

CAS: 26833-87-4

• Formula: C₂₉H₃₉NO₉
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 545.62

Omacetaxine Mepesuccinate (Homoharringtonine)

CAS: 26833-87-4

• Formula: C₂₉H₃₉NO₉
• Color and Shape: White To Off-White Solid
• Molecular weight: 545.63

Homoharringtonine

CAS: 26833-87-4

• Purity: ≥98%
• Molecular weight: 545.62g/mol

Homoharringtonine

CAS: 26833-87-4

• Formula: C₂₉H₃₉NO₉
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 545.63

Homoharringtonine

CAS: 26833-87-4

• Formula: C₂₉H₃₉NO₉
• Purity: 95%~99%
• Molecular weight: 545.629

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat …

• Formula: C₂₉H₃₉NO₉
• Purity: 98.21% - 99.54%
• Color and Shape: Off-White Cryst
• Molecular weight: 545.62

Homoharringtonine

CAS: 26833-87-4

Natural alkaloid

• Formula: C₂₉H₃₉NO₉
• Purity: ≥ 95.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 545.63

Homoharringtonine

CAS: 26833-87-4

Applications Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal …

• Formula: C₂₉H₃₉NO₉
• Color and Shape: Neat
• Molecular weight: 545.62

Homoharringtonine

CAS: 26833-87-4

Please enquire for more information about Homoharringtonine including the price, delivery time and more detailed …

• Formula: C₂₉H₃₉NO₉
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 545.62 g/mol

Homoharringtonine - Bio-X ™

CAS: 26833-87-4

This product is part of our Bio-X ™ Range. These products are aimed at life …

• Formula: C₂₉H₃₉NO₉
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 545.62 g/mol