CAS 26833-87-4

Homoharringtonine

Description:

Homoharringtonine, with the CAS number 26833-87-4, is a natural alkaloid derived from the plant species Cephalotaxus harringtonia. It is primarily known for its role as an antineoplastic agent, particularly in the treatment of certain types of leukemia, such as acute myeloid leukemia (AML). The compound functions by inhibiting protein synthesis, which ultimately leads to the suppression of cancer cell proliferation. Homoharringtonine exhibits a unique mechanism of action by targeting the eukaryotic translation initiation process, making it distinct from other chemotherapeutic agents. It is typically administered intravenously and has been studied for its efficacy in combination with other chemotherapy drugs. The substance is characterized by its complex molecular structure, which includes multiple chiral centers, contributing to its biological activity. While it shows promise in clinical applications, its use may be associated with side effects, including myelosuppression and gastrointestinal disturbances. Ongoing research continues to explore its potential and optimize its therapeutic use in oncology.

Formula: C₂₉H₃₉NO₉

InChI: InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1

InChI key: InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N

SMILES: O(C([C@@](CCCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]

Synonyms:

• (4alpha)-O~3~-[2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Brn 5687925
• Ceflatonin
• Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI)
• Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI)
• Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cgx-635
• Myelostat
• Nsc 141633
• Omacetaxine mepesuccinate
• Omacetaxine mepesuccinate [USAN]
• Omapro
• O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• Synribo
• Unii-6Fg8041S5B

Omacetaxine Mepesuccinate (Homoharringtonine)

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Color and Shape: White To Off-White Solid

Molecular weight: 545.63

Ref: 4Z-O-027001

Homoharringtonine

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 545.62

Ref: 7W-GP6715

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine

Purity: ≥98%

Molecular weight: 545.62g/mol

Ref: 54-BUP10774

Homoharringtonine

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 545.63

Ref: 3B-H1775

Homoharringtonine

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Purity: 95%~99%

Molecular weight: 545.629

Ref: BP-BP0732

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.

Formula: C₂₉H₃₉NO₉

Purity: 98.21% - 99.91%

Color and Shape: Off-White Cryst

Molecular weight: 545.62

Ref: TM-T3380

Homoharringtonine

CAS: 26833-87-4

Natural alkaloid

Formula: C₂₉H₃₉NO₉

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 545.63

Ref: 5G-89708

Homoharringtonine

Controlled Product

CAS: 26833-87-4

Applications Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of α-ketoester harringtonine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baaske, D., et al.: Antimicrob. Agents Chemother., 12, 298 (1977), Tipping, A., et al.: Leukemia, 16, 2349 (2002), Marin, D., et al.: Cancer, 103, 1850 (2005), Levy, V., et al.: Br. J. Cancer, 95, 253 (2006), de Lavallade, H., et al.: Blood, 2779 (2007),

Formula: C₂₉H₃₉NO₉

Color and Shape: Neat

Molecular weight: 545.62

Ref: TR-H596500

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine is an alkaloid isolated as an anticancer agent, which is derived from the Cephalotaxus genus of evergreen trees and shrubs. It is specifically extracted from the leaves and bark, traditionally known for its therapeutic applications in Chinese medicine. The mode of action of Homoharringtonine involves the inhibition of protein synthesis. It achieves this by binding to the A-site of the ribosomal subunit, impeding the elongation phase of protein synthesis and thus disrupting cellular proliferation.

Formula: C₂₉H₃₉NO₉

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 545.62 g/mol

Ref: 3D-FH15974

Homoharringtonine - Bio-X ™

CAS: 26833-87-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₉H₃₉NO₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 545.62 g/mol

Ref: 3D-BH300085

Homoharringtonine

CAS: 26833-87-4

Purity: 99%

Molecular weight: 545.629

Ref: 10-F979707